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Page 1
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α.
A M, Wales TE, Zhou H, Draga-Coletă SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang ZF, Jedrychowski MP, Seo HS, Song K, Xu AZ, Sebastian L, Gygi SP, Arthanari H, Dhe-Paganon S, Griffin PR, Engen JR, Spiegelman BM. A M, et al. Among authors: gorgulla c. Mol Cell. 2023 Jun 1;83(11):1903-1920.e12. doi: 10.1016/j.molcel.2023.05.008. Mol Cell. 2023. PMID: 37267907 Free PMC article.
An open-source drug discovery platform enables ultra-large virtual screens.
Gorgulla C, Boeszoermenyi A, Wang ZF, Fischer PD, Coote PW, Padmanabha Das KM, Malets YS, Radchenko DS, Moroz YS, Scott DA, Fackeldey K, Hoffmann M, Iavniuk I, Wagner G, Arthanari H. Gorgulla C, et al. Nature. 2020 Apr;580(7805):663-668. doi: 10.1038/s41586-020-2117-z. Epub 2020 Mar 9. Nature. 2020. PMID: 32152607 Free PMC article.
A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening.
Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. Gorgulla C, et al. iScience. 2021 Feb 19;24(2):102021. doi: 10.1016/j.isci.2020.102021. Epub 2021 Jan 5. iScience. 2021. PMID: 33426509 Free PMC article.
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML, Wagner G. Zhang M, et al. Among authors: gorgulla c. Nat Struct Mol Biol. 2021 Mar;28(3):258-267. doi: 10.1038/s41594-020-00554-6. Epub 2021 Feb 25. Nat Struct Mol Biol. 2021. PMID: 33633398 Free PMC article.
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.
Fischer PD, Papadopoulos E, Dempersmier JM, Wang ZF, Nowak RP, Donovan KA, Kalabathula J, Gorgulla C, Junghanns PPM, Kabha E, Dimitrakakis N, Petrov OI, Mitsiades C, Ducho C, Gelev V, Fischer ES, Wagner G, Arthanari H. Fischer PD, et al. Among authors: gorgulla c. Eur J Med Chem. 2021 Jul 5;219:113435. doi: 10.1016/j.ejmech.2021.113435. Epub 2021 Apr 8. Eur J Med Chem. 2021. PMID: 33892272 Free PMC article.
Targeting ROS production through inhibition of NADPH oxidases.
Reis J, Gorgulla C, Massari M, Marchese S, Valente S, Noce B, Basile L, Törner R, Cox H 3rd, Viennet T, Yang MH, Ronan MM, Rees MG, Roth JA, Capasso L, Nebbioso A, Altucci L, Mai A, Arthanari H, Mattevi A. Reis J, et al. Among authors: gorgulla c. Nat Chem Biol. 2023 Dec;19(12):1540-1550. doi: 10.1038/s41589-023-01457-5. Epub 2023 Oct 26. Nat Chem Biol. 2023. PMID: 37884805
22 results