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Page 1
A complex systems model of breast cancer etiology: The Paradigm II Model.
Hiatt RA, Worden L, Rehkopf D, Engmann N, Troester M, Witte JS, Balke K, Jackson C, Barlow J, Fenton SE, Gehlert S, Hammond RA, Kaplan G, Kornak J, Nishioka K, McKone T, Smith MT, Trasande L, Porco TC. Hiatt RA, et al. Among authors: witte js. PLoS One. 2023 May 19;18(5):e0282878. doi: 10.1371/journal.pone.0282878. eCollection 2023. PLoS One. 2023. PMID: 37205649 Free PMC article.
The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics.
Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. Yee SW, et al. Among authors: witte js. bioRxiv [Preprint]. 2023 Jun 7:2023.06.06.543963. doi: 10.1101/2023.06.06.543963. bioRxiv. 2023. Update in: Mol Cell. 2024 May 16;84(10):1932-1947.e10. doi: 10.1016/j.molcel.2024.04.008. PMID: 37333090 Free PMC article. Updated. Preprint.
The PRIMED Consortium: Reducing disparities in polygenic risk assessment.
Kullo IJ, Conomos MP, Nelson SC, Adebamowo SN, Choudhury A, Conti D, Fullerton SM, Gogarten SM, Heavner B, Hornsby WE, Kenny EE, Khan A, Khera AV, Li Y, Martin I, Mercader JM, Ng M, Raffield LM, Reiner A, Rowley R, Schaid D, Stilp A, Wiley K, Wilson R, Witte JS, Natarajan P; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium. Kullo IJ, et al. Among authors: witte js. Am J Hum Genet. 2024 Dec 5;111(12):2594-2606. doi: 10.1016/j.ajhg.2024.10.010. Epub 2024 Nov 18. Am J Hum Genet. 2024. PMID: 39561770 Free PMC article.
A Polygenic Risk Score for Prostate Cancer Risk Prediction.
Schaffer KR, Shi M, Shelley JP, Tosoian JJ, Kachuri L, Witte JS, Mosley JD. Schaffer KR, et al. Among authors: witte js. JAMA Intern Med. 2023 Apr 1;183(4):386-388. doi: 10.1001/jamainternmed.2022.6795. JAMA Intern Med. 2023. PMID: 36877498 Free PMC article.
SLCO1B1 Functional Variants, Bilirubin, Statin-Induced Myotoxicity, and Recent Sub-Saharan African Ancestry: A Precision Medicine Health Equity Study.
Haldar T, Kvale M, Yang J, Douglas MP, Coyote-Maetas W, Kachuri L, Witte JS, Iribarren C, Medina MW, Krauss RM, Yee SW, Oni-Orisan A. Haldar T, et al. Among authors: witte js. Clin Pharmacol Ther. 2025 Jun;117(6):1696-1705. doi: 10.1002/cpt.3624. Epub 2025 Mar 6. Clin Pharmacol Ther. 2025. PMID: 40047317 Free article.
Tumor Necrosis Factor-Alpha Inhibitor Use and Malignancy Risk: A Systematic Review and Patient Level Meta-Analysis.
Driscoll CB, Rich JM, Isaacson D, Nicolas J, Jiang Y, Mi X, Yang C, Kocsuta V, Goh R, Patel N, Li E, Siddiqui MR, Meyers T, Witte JS, Kachuri L, Zhang H, Beestrum M, Silberman P, Schaeffer EM, Kundu SD. Driscoll CB, et al. Among authors: witte js. Cancers (Basel). 2025 Jan 24;17(3):390. doi: 10.3390/cancers17030390. Cancers (Basel). 2025. PMID: 39941759 Free PMC article. Review.
307 results