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The mitochondriotropic antioxidants AntiOxBEN2 and AntiOxCIN4 are structurally-similar but differentially alter energy homeostasis in human skin fibroblasts.
Teixeira J, Benfeito S, Carreira R, Barbosa A, Amorim R, Tavares LC, Jones JG, Raimundo N, Cagide F, Oliveira C, Borges F, Koopman WJH, Oliveira PJ. Teixeira J, et al. Among authors: raimundo n. Biochim Biophys Acta Bioenerg. 2025 Apr 1;1866(2):149535. doi: 10.1016/j.bbabio.2025.149535. Epub 2025 Jan 7. Biochim Biophys Acta Bioenerg. 2025. PMID: 39788276
Role of lipids in interorganelle communication.
Domingues N, Pires J, Milosevic I, Raimundo N. Domingues N, et al. Among authors: raimundo n. Trends Cell Biol. 2025 Jan;35(1):46-58. doi: 10.1016/j.tcb.2024.04.008. Epub 2024 Jun 11. Trends Cell Biol. 2025. PMID: 38866684 Review.
Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida.
Rogina B, Anderson R, LeBrasseur NK, Curran SP, Yousefzadeh MJ, Ghosh B, Duque G, Howlett S, Austad S, Demuth I, Gerstorf D, Korfhage J, Lombard DB, Abadir P, Christensen K, Carey JR, Alberts SC, Campos F, Palavicini JP, Palmer A, Bell J, Basisty N, de Cabo R, Gomes A, Dixit VD, Sen P, Baur JA, Imai SI, Li X, Valdez G, Orr ME, Pletcher S, Andersen J, Jones L, Castillo-Azofeida D, Bonaguidi M, Suh Y, Duncan FE, Murray A, Wang MC, Burkewitz K, Henne M, Zhou K, Bouhrara M, Benjamini D, Kolind S, Walker KA, Reiter DA, Dean DC 3rd, Gorbunova V, Gladyshev VN, Palovics R, Niedernhofer LJ, Fan R, Bueckle AD, Hurley J, Esser KA, Kapahi P, Sato S, Jiang N, Ashiqueali SA, Diaz J, Mishra SP, Raimundo N, Banarjee R, Allsopp R, Reynolds LM, Zhang B, Sebastiani P, Monti S, Schork N, Rappaport N. Rogina B, et al. Among authors: raimundo n. J Gerontol A Biol Sci Med Sci. 2025 Apr 7;80(5):glaf026. doi: 10.1093/gerona/glaf026. J Gerontol A Biol Sci Med Sci. 2025. PMID: 39932386
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Antičević I, Otten C, Torrecilla I, Koukouravas S, Zhao Y, Yang H, Aljarbou F, Ruggiano A, Song W, Peron C, Deangeli G, Domingo E, Bancroft J, Carrique L, Johnson E, Vendrell I, Fischer R, Ng AWT, Ngeow J, D'Angiolella V, Raimundo N, Maughan T, Popović M, Milošević I, Ramadan K. Lascaux P, et al. Among authors: raimundo n. Cell. 2024 Oct 3;187(20):5698-5718.e26. doi: 10.1016/j.cell.2024.08.020. Epub 2024 Sep 11. Cell. 2024. PMID: 39265577 Free article.
Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling.
Domingues N, Catarino S, Cristóvão B, Rodrigues L, Carvalho FA, Sarmento MJ, Zuzarte M, Almeida J, Ribeiro-Rodrigues T, Correia-Rodrigues Â, Fernandes F, Rodrigues-Santos P, Aasen T, Santos NC, Korolchuk VI, Gonçalves T, Milosevic I, Raimundo N, Girão H. Domingues N, et al. Among authors: raimundo n. EMBO J. 2024 Sep;43(17):3627-3649. doi: 10.1038/s44318-024-00177-3. Epub 2024 Jul 23. EMBO J. 2024. PMID: 39044100 Free PMC article.
Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling.
Domingues N, Calcagni' A, Pires J, Freire SR, Herz NJ, Huynh T, Wieciorek K, Moreno MJ, Outeiro TF, Girão H, Milosevic I, Ballabio A, Raimundo N. Domingues N, et al. Among authors: raimundo n. bioRxiv [Preprint]. 2024 Jun 2:2024.05.31.596474. doi: 10.1101/2024.05.31.596474. bioRxiv. 2024. PMID: 38853929 Free PMC article. Preprint.
Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain.
Agostini F, Pereyra L, Dale J, Yambire KF, Maglioni S, Schiavi A, Ventura N, Milosevic I, Raimundo N. Agostini F, et al. Among authors: raimundo n. bioRxiv [Preprint]. 2024 Mar 7:2024.03.06.583589. doi: 10.1101/2024.03.06.583589. bioRxiv. 2024. Update in: J Biol Chem. 2024 Jul;300(7):107403. doi: 10.1016/j.jbc.2024.107403. PMID: 38496624 Free PMC article. Updated. Preprint.
53 results