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Page 1
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss.
Cal K, Leyva A, Rodríguez-Duarte J, Ruiz S, Santos L, Garat MP, Colella L, Ingold M, Benitez-Rosendo A, Pérez-Torrado V, Vilaseca C, Galliussi G, Ziegler L, Peclat TR, Bresque M, Handy RM, King R, Menezes Dos Reis L, Alves JM, Espasandín C, de la Sovera V, Breining P, Dapueto R, Lopez A, Thompson KL, Lino CA, França JV, Vieira TS, Rattan R, Agorrody G, DeVallance E, Haag J, Meadows E, Lewis SE, Santana Barbosa GC, Lai de Souza LO, Chichierchio MS, Valez V, Aicardo A, Contreras P, Vendelbo MH, Jakobsen S, Kamaid A, Porcal W, Calliari A, Verdes JM, Du J, Wang Y, Hollander JM, White TA, Radi R, Moyna G, Quijano C, O'Doherty R, Moraes-Vieira P, Giri S, Holloway GP, Festuccia WT, Leiria LO, Leonardi R, Mori MA, Camacho-Pereira J, Kelley EE, Duran R, López GV, Chini EN, Batthyány C, Escande C. Cal K, et al. Among authors: chichierchio ms. Nat Metab. 2025 Jun 17. doi: 10.1038/s42255-025-01311-z. Online ahead of print. Nat Metab. 2025. PMID: 40527924
Chikungunya virus infection under high glucose environment reverts insulin unresponsiveness and promotes cellular metabolic shift to increase anaplerosis and virion production.
Rajsfus BF, Nascimento-Júnior JX, Chichierchio MS, Todeschini AR, Oliveira IA, Borges FS, Barroso SP, Mohana-Borges R, Camacho-Pereira J, Zancan P, Allonso D. Rajsfus BF, et al. Among authors: chichierchio ms. Life Sci. 2025 Sep 1;376:123729. doi: 10.1016/j.lfs.2025.123729. Epub 2025 May 20. Life Sci. 2025. PMID: 40404124
The NADase CD38 may not dictate NAD levels in brain mitochondria of aged mice but regulates hydrogen peroxide generation.
Camacho-Pereira J, Lai de Souza LO, Chichierchio MS, Rodrigues-Chaves C, Lomba LS, Fonseca-Oliveira M, Carvalho-Mendonça D, Silva-Rodrigues T, Galina A. Camacho-Pereira J, et al. Among authors: chichierchio ms. Free Radic Biol Med. 2023 Nov 20;209(Pt 1):29-39. doi: 10.1016/j.freeradbiomed.2023.09.035. Epub 2023 Sep 28. Free Radic Biol Med. 2023. PMID: 37774804 Free article.
A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis.
Cal K, Leyva A, Rodríguez-Duarte J, Ruiz S, Santos L, Colella L, Ingold M, Vilaseca C, Galliussi G, Ziegler L, Peclat TR, Bresque M, Handy RM, King R, Dos Reis LM, Espasandin C, Breining P, Dapueto R, Lopez A, Thompson KL, Agorrody G, DeVallance E, Meadows E, Lewis SE, Barbosa GCS, de Souza LOL, Chichierchio MS, Valez V, Aicardo A, Contreras P, Vendelbo MH, Jakobsen S, Kamaid A, Porcal W, Calliari A, Verdes JM, Du J, Wang Y, Hollander JM, White TA, Radi R, Moyna G, Quijano C, O'Doherty R, Moraes-Vieira P, Holloway GP, Leonardi R, Mori MA, Camacho-Pereira J, Kelley EE, Duran R, Lopez GV, Batthyány C, Chini EN, Escande C. Cal K, et al. Among authors: chichierchio ms. Res Sq [Preprint]. 2023 Jul 12:rs.3.rs-3101395. doi: 10.21203/rs.3.rs-3101395/v1. Res Sq. 2023. Update in: Nat Metab. 2025 Jun 17. doi: 10.1038/s42255-025-01311-z. PMID: 37502859 Free PMC article. Updated. Preprint.