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Flipped C-Terminal Ends of APOA1 Promote ABCA1-dependent Cholesterol Efflux by Small HDLs.
He Y, Pavanello C, Hutchins PM, Tang C, Pourmousa M, Vaisar T, Song HD, Pastor RW, Remaley AT, Goldberg IJ, Costacou T, Davidson WS, Bornfeldt KE, Calabresi L, Segrest JP, Heinecke JW. He Y, et al. Among authors: bornfeldt ke. medRxiv [Preprint]. 2023 Nov 4:2023.11.03.23297986. doi: 10.1101/2023.11.03.23297986. medRxiv. 2023. Update in: Circulation. 2024 Mar 5;149(10):774-787. doi: 10.1161/CIRCULATIONAHA.123.065959. PMID: 37961344 Free PMC article. Updated. Preprint.
APOA2 increases cholesterol efflux capacity to plasma HDL by displacing the C-terminus of resident APOA1.
Sarkar S, Morris J, You Y, Sexmith H, Street SE, Thibert SM, Attah IK, Hutchinson Bunch CM, Novikova IV, Evans JE, Shah AS, Gordon SM, Segrest JP, Bornfeldt KE, Vaisar T, Heinecke JW, Davidson WS, Melchior JT. Sarkar S, et al. Among authors: bornfeldt ke. J Lipid Res. 2024 Dec;65(12):100686. doi: 10.1016/j.jlr.2024.100686. Epub 2024 Oct 28. J Lipid Res. 2024. PMID: 39490930 Free PMC article.
Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL.
Coleman B, Bedi S, Hill JH, Morris J, Manthei KA, Hart RC, He Y, Shah AS, Jerome WG, Vaisar T, Bornfeldt KE, Song H, Segrest JP, Heinecke JW, Aller SG, Tesmer JJG, Davidson WS. Coleman B, et al. Among authors: bornfeldt ke. J Lipid Res. 2025 May;66(5):100786. doi: 10.1016/j.jlr.2025.100786. Epub 2025 Mar 25. J Lipid Res. 2025. PMID: 40147634 Free PMC article.
177 results