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LSD1 inhibition suppresses ASCL1 and de-represses YAP1 to drive potent activity against neuroendocrine prostate cancer.
Mandl A, Jasmine S, Krueger T, Kumar R, Coleman IM, Dalrymple SL, Antony L, Rosen DM, Jing Y, Hanratty B, Patel RA, Jin-Yih L, Dias J, Celatka CA, Tapper AE, Kleppe M, Kanayama M, Speranzini V, Wang YZ, Luo J, Corey E, Sena LA, Casero RA, Lotan T, Trock BJ, Kachhap SK, Denmeade SR, Carducci MA, Mattevi A, Haffner MC, Nelson PS, Rienhoff HY, Isaacs JT, Brennen WN. Mandl A, et al. Among authors: patel ra. bioRxiv [Preprint]. 2024 Jan 22:2024.01.17.576106. doi: 10.1101/2024.01.17.576106. bioRxiv. 2024. PMID: 38328141 Free PMC article. Preprint.
Patterns of intra- and inter-tumor phenotypic heterogeneity in lethal prostate cancer.
Roudier MP, Gulati R, Sayar E, Patel RA, Tratt M, Richards HM, Cejas P, Munoz Gomez M, Qiu X, Xie Y, Hanratty B, Zaidi S, Zhao JL, Adil M, Mittal C, Zhao Y, Dumpit R, Coleman I, Low JY, Persse T, Galipeau PC, Lee JK, Tretiakova M, Chambers M, Vakar-Lopez F, True LD, Perrone M, Lam HM, Kollath LA, Ding CC, Harmon S, Cheng HH, Yu EY, Montgomery RB, Hawley JE, Lin DW, Corey E, Schweizer MT, Setty M, Ha G, Sawyers CL, Morrissey C, Long HW, Nelson PS, Haffner MC. Roudier MP, et al. Among authors: patel ra. J Clin Invest. 2025 Jun 10:e186599. doi: 10.1172/JCI186599. Online ahead of print. J Clin Invest. 2025. PMID: 40493417 Free article.
PROX1 is an early driver of lineage plasticity in prostate cancer.
Duan Z, Shi M, Kumaraswamy A, Lin D, Khokhani D, Wang Y, Zhang C, Flores D, Rodansky E, Swaim OA, Storck WK, Beck HN, Patel RA, Sayar E, Hanratty BP, Xue H, Dong X, Maylin ZR, Wan R, Quigley DA, Sjöström M, Hu YM, Zhao F, Xia Z, Cheng S, Yu X, Feng FY, Zhang L, Aggarwal R, Small EJ, Ravikumar V, Rao A, Bedi K, Lee JK, Morrissey C, Coleman I, Nelson PS, Corey E, Udager AM, Rebernick RJ, Cieslik MP, Chinnaiyan AM, Yates JA, Haffner MC, Wang Y, Alumkal JJ. Duan Z, et al. Among authors: patel ra. J Clin Invest. 2025 Jun 2;135(11):e187490. doi: 10.1172/JCI187490. eCollection 2025 Jun 2. J Clin Invest. 2025. PMID: 40454483 Free PMC article.
314 results