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Page 1
Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression.
Zabransky DJ, Chhabra Y, Fane ME, Kartalia E, Leatherman JM, Hüser L, Zimmerman JW, Delitto D, Han S, Armstrong TD, Charmsaz S, Guinn S, Pramod S, Thompson ED, Hughes SJ, O'Connell J, Egan JM, Jaffee EM, Weeraratna AT. Zabransky DJ, et al. Among authors: guinn s. Cancer Res. 2024 Apr 15;84(8):1221-1236. doi: 10.1158/0008-5472.CAN-24-0086. Cancer Res. 2024. PMID: 38330147 Free PMC article.
Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resection.
Delitto D, Zabransky DJ, Chen F, Thompson ED, Zimmerman JW, Armstrong TD, Leatherman JM, Suri R, Lopez-Vidal TY, Huff AL, Lyman MR, Guinn SR, Baretti M, Kagohara LT, Ho WJ, Azad NS, Burns WR, He J, Wolfgang CL, Burkhart RA, Zheng L, Yarchoan M, Zaidi N, Jaffee EM. Delitto D, et al. Among authors: guinn sr. Oncoimmunology. 2021 Nov 8;10(1):2001159. doi: 10.1080/2162402X.2021.2001159. eCollection 2021. Oncoimmunology. 2021. PMID: 34777919 Free PMC article.
Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma.
Wehrli M, Guinn S, Birocchi F, Kuo A, Sun Y, Larson RC, Almazan AJ, Scarfò I, Bouffard AA, Bailey SR, Anekal PV, Montero Llopis P, Nieman LT, Song Y, Xu KH, Berger TR, Kann MC, Leick MB, Silva H, Salas-Benito D, Kienka T, Grauwet K, Armstrong TD, Zhang R, Zhu Q, Fu J, Schmidts A, Korell F, Jan M, Choi BD, Liss AS, Boland GM, Ting DT, Burkhart RA, Jenkins RW, Zheng L, Jaffee EM, Zimmerman JW, Maus MV. Wehrli M, et al. Among authors: guinn s. Clin Cancer Res. 2024 May 1;30(9):1859-1877. doi: 10.1158/1078-0432.CCR-23-3841. Clin Cancer Res. 2024. PMID: 38393682 Free PMC article.
Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma.
Guinn S, Kinny-Köster B, Tandurella JA, Mitchell JT, Sidiropoulos DN, Loth M, Lyman MR, Pucsek AB, Zabransky DJ, Lee JW, Kartalia E, Ramani M, Seppälä TT, Cherry C, Suri R, Zlomke H, Patel J, He J, Wolfgang CL, Yu J, Zheng L, Ryan DP, Ting DT, Kimmelman A, Gupta A, Danilova L, Elisseeff JH, Wood LD, Stein-O'Brien G, Kagohara LT, Jaffee EM, Burkhart RA, Fertig EJ, Zimmerman JW. Guinn S, et al. Cancer Res. 2024 May 2;84(9):1517-1533. doi: 10.1158/0008-5472.CAN-23-1660. Cancer Res. 2024. PMID: 38587552 Free PMC article.
Patient-derived Organoid Pharmacotyping As A Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma.
Nicolson NG, Tandurella JA, Wu LW, Patel J, Morris E, Seppälä TT, Guinn S, Zlomke H, Shubert CR, Lafaro KJ, Burns WR, Cameron JL, He J, Fertig EJ, Jaffee EM, Zimmerman JW, Burkhart RA. Nicolson NG, et al. Among authors: guinn s. Ann Surg. 2024 Sep 4:10.1097/SLA.0000000000006517. doi: 10.1097/SLA.0000000000006517. Online ahead of print. Ann Surg. 2024. PMID: 39229726
Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression.
Guinn S, Perez B, Tandurella JA, Ramani M, Lee JW, Zabransky DJ, Kartalia E, Patel J, Zlomke H, Nicolson N, Shin S, Barrett B, Sun N, Hernandez A, Coyne E, Cannon C, Gross NE, Charmsaz S, Cho Y, Leatherman J, Lyman M, Mitchell J, Kagohara LT, Goggins MG, Lafaro KJ, He J, Shubert C, Burns W, Zheng L, Fertig EJ, Jaffee EM, Burkhart RA, Ho WJ, Zimmerman JW. Guinn S, et al. bioRxiv [Preprint]. 2025 Jan 8:2025.01.07.631784. doi: 10.1101/2025.01.07.631784. bioRxiv. 2025. PMID: 39829906 Free PMC article. Preprint.
Spatial Proteomics and Transcriptomics Reveal Early Immune Cell Organization in Pancreatic Intraepithelial Neoplasia.
Lyman MR, Mitchell JT, Raghavan S, Kagohara LT, Huff AL, Haldar SD, Shin SM, Guinn S, Barrett B, Longway G, Hernandez A, Coyne EM, Yuan X, Andaloori L, Lai J, Liu YZ, Karchin R, Gupta A, Kiemen AL, Forjaz A, Wirtz D, Wu PH, Deshpande A, Lee JW, Armstrong TD, Azad NS, Zimmerman JW, Wood LD, Anders RA, Thompson ED, Jaffee EM, Fertig EJ, Ho WJ, Zaidi N. Lyman MR, et al. Among authors: guinn s. JCI Insight. 2025 Jun 26:e191595. doi: 10.1172/jci.insight.191595. Online ahead of print. JCI Insight. 2025. PMID: 40569674 Free article.
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment.
Pauken KE, Shahid O, Lagattuta KA, Mahuron KM, Luber JM, Lowe MM, Huang L, Delaney C, Long JM, Fung ME, Newcomer K, Tsai KK, Chow M, Guinn S, Kuchroo JR, Burke KP, Schenkel JM, Rosenblum MD, Daud AI, Sharpe AH, Singer M. Pauken KE, et al. Among authors: guinn s. J Exp Med. 2021 Apr 5;218(4):e20200920. doi: 10.1084/jem.20200920. J Exp Med. 2021. PMID: 33651880 Free PMC article.
21 results