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Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Membrez M, et al. Among authors: treebak jt. Nat Metab. 2024 Mar;6(3):433-447. doi: 10.1038/s42255-024-00997-x. Epub 2024 Mar 19. Nat Metab. 2024. PMID: 38504132 Free PMC article.
Perturbations of NAD+ salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle.
Agerholm M, Dall M, Jensen BAH, Prats C, Madsen S, Basse AL, Graae AS, Risis S, Goldenbaum J, Quistorff B, Larsen S, Vienberg SG, Treebak JT. Agerholm M, et al. Among authors: treebak jt. Am J Physiol Endocrinol Metab. 2018 Apr 1;314(4):E377-E395. doi: 10.1152/ajpendo.00213.2017. Epub 2017 Dec 5. Am J Physiol Endocrinol Metab. 2018. PMID: 29208611 Free article.
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle.
Rhein P, Desjardins EM, Rong P, Ahwazi D, Bonhoure N, Stolte J, Santos MD, Ovens AJ, Ehrlich AM, Sanchez Garcia JL, Ouyang Q, Yabut JM, Kjolby M, Membrez M, Jessen N, Oakhill JS, Treebak JT, Maire P, Scott JW, Sanders MJ, Descombes P, Chen S, Steinberg GR, Sakamoto K. Rhein P, et al. Among authors: treebak jt. Mol Metab. 2021 Sep;51:101228. doi: 10.1016/j.molmet.2021.101228. Epub 2021 Mar 30. Mol Metab. 2021. PMID: 33798773 Free PMC article.
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity.
Basse AL, Agerholm M, Farup J, Dalbram E, Nielsen J, Ørtenblad N, Altıntaş A, Ehrlich AM, Krag T, Bruzzone S, Dall M, de Guia RM, Jensen JB, Møller AB, Karlsen A, Kjær M, Barrès R, Vissing J, Larsen S, Jessen N, Treebak JT. Basse AL, et al. Among authors: treebak jt. Mol Metab. 2021 Nov;53:101271. doi: 10.1016/j.molmet.2021.101271. Epub 2021 Jun 11. Mol Metab. 2021. PMID: 34119711 Free PMC article.
123 results