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Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists.
Kosar M, Sarott RC, Sykes DA, Viray AEG, Vitale RM, Tomašević N, Li X, Ganzoni RLZ, Kicin B, Reichert L, Patej KJ, Gómez-Bouzó U, Guba W, McCormick PJ, Hua T, Gruber CW, Veprintsev DB, Frank JA, Grether U, Carreira EM. Kosar M, et al. Among authors: gruber cw. ACS Cent Sci. 2024 Mar 11;10(5):956-968. doi: 10.1021/acscentsci.3c01461. eCollection 2024 May 22. ACS Cent Sci. 2024. PMID: 38799662 Free PMC article.
Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling.
Muratspahić E, Tomašević N, Nasrollahi-Shirazi S, Gattringer J, Emser FS, Freissmuth M, Gruber CW. Muratspahić E, et al. Among authors: gruber cw. J Nat Prod. 2021 Aug 27;84(8):2238-2248. doi: 10.1021/acs.jnatprod.1c00301. Epub 2021 Jul 26. J Nat Prod. 2021. PMID: 34308635 Free PMC article.
Chemical synthesis of grafted cyclotides using a "plug and play" approach.
Koehbach J, Muratspahić E, Ahmed ZM, White AM, Tomašević N, Durek T, Clark RJ, Gruber CW, Craik DJ. Koehbach J, et al. Among authors: gruber cw. RSC Chem Biol. 2024 Apr 29;5(6):567-571. doi: 10.1039/d4cb00008k. eCollection 2024 Jun 5. RSC Chem Biol. 2024. PMID: 38846076 Free PMC article.
Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain.
Muratspahić E, Tomašević N, Koehbach J, Duerrauer L, Hadžić S, Castro J, Schober G, Sideromenos S, Clark RJ, Brierley SM, Craik DJ, Gruber CW. Muratspahić E, et al. Among authors: gruber cw. J Med Chem. 2021 Jul 8;64(13):9042-9055. doi: 10.1021/acs.jmedchem.1c00158. Epub 2021 Jun 23. J Med Chem. 2021. PMID: 34162205 Free PMC article.
108 results