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Neuroendocrine gut-brain signaling in obesity.
Gruber T, Lechner F, Krieger JP, García-Cáceres C. Gruber T, et al. Trends Endocrinol Metab. 2025 Jan;36(1):42-54. doi: 10.1016/j.tem.2024.05.002. Epub 2024 May 30. Trends Endocrinol Metab. 2025. PMID: 38821753 Free article. Review.
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses.
Zani F, Blagih J, Gruber T, Buck MD, Jones N, Hennequart M, Newell CL, Pilley SE, Soro-Barrio P, Kelly G, Legrave NM, Cheung EC, Gilmore IS, Gould AP, Garcia-Caceres C, Vousden KH. Zani F, et al. Nature. 2023 Mar;615(7953):705-711. doi: 10.1038/s41586-023-05801-6. Epub 2023 Mar 15. Nature. 2023. PMID: 36922598 Free PMC article.
High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.
Gruber T, Lechner F, Murat C, Contreras RE, Sanchez-Quant E, Miok V, Makris K, Le Thuc O, González-García I, García-Clave E, Althammer F, Krabichler Q, DeCamp LM, Jones RG, Lutter D, Williams RH, Pfluger PT, Müller TD, Woods SC, Pospisilik JA, Martinez-Jimenez CP, Tschöp MH, Grinevich V, García-Cáceres C. Gruber T, et al. Cell Rep. 2023 Oct 31;42(10):113305. doi: 10.1016/j.celrep.2023.113305. Cell Rep. 2023. PMID: 37864798 Free PMC article.
Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.
Grandl G, Collden G, Feng J, Bhattacharya S, Klingelhuber F, Schomann L, Bilekova S, Ansarullah, Xu W, Far FF, Tost M, Gruber T, Bastidas-Ponce A, Zhang Q, Novikoff A, Liskiewicz A, Liskiewicz D, Garcia-Caceres C, Feuchtinger A, Tschöp MH, Krahmer N, Lickert H, Müller TD. Grandl G, et al. Nat Metab. 2024 Mar;6(3):448-457. doi: 10.1038/s42255-024-00991-3. Epub 2024 Feb 28. Nat Metab. 2024. PMID: 38418586 Free PMC article.
Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes.
Goll N, Moszka N, Kantartzis K, Preissl H, Gruber T, Fritsche L, Jumpertz-von Schwarzenberg R, García-Cáceres C, Fritsche A, Hallschmid M. Goll N, et al. Among authors: garcia caceres c. Diabetes Obes Metab. 2024 Oct;26(10):4562-4570. doi: 10.1111/dom.15812. Epub 2024 Aug 8. Diabetes Obes Metab. 2024. PMID: 39118203 Clinical Trial.
Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice.
Liskiewicz D, Zhang Q, Barthem CS, Jastroch M, Liskiewicz A, Khajavi N, Grandl G, Coupland C, Kleinert M, Garcia-Caceres C, Novikoff A, Maity G, Boehm U, Tschöp MH, Müller TD. Liskiewicz D, et al. Mol Metab. 2023 Jun;72:101714. doi: 10.1016/j.molmet.2023.101714. Epub 2023 Mar 24. Mol Metab. 2023. PMID: 36966947 Free PMC article.
The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes.
Giroud M, Kotschi S, Kwon Y, Le Thuc O, Hoffmann A, Gil-Lozano M, Karbiener M, Higareda-Almaraz JC, Khani S, Tews D, Fischer-Posovszky P, Sun W, Dong H, Ghosh A, Wolfrum C, Wabitsch M, Virtanen KA, Blüher M, Nielsen S, Zeigerer A, García-Cáceres C, Scheideler M, Herzig S, Bartelt A. Giroud M, et al. EMBO Rep. 2023 Oct 9;24(10):e57600. doi: 10.15252/embr.202357600. Epub 2023 Sep 6. EMBO Rep. 2023. PMID: 37671834 Free PMC article.
The interactions between energy homeostasis and neurovascular plasticity.
Chen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. Chen B, et al. Among authors: garcia caceres c. Nat Rev Endocrinol. 2024 Dec;20(12):749-759. doi: 10.1038/s41574-024-01021-8. Epub 2024 Jul 25. Nat Rev Endocrinol. 2024. PMID: 39054359 Review.
83 results