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Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity.
Saville KM, Al-Rahahleh RQ, Siddiqui AH, Andrews ME, Roos WP, Koczor CA, Andrews JF, Hayat F, Migaud ME, Sobol RW. Saville KM, et al. Among authors: al rahahleh rq. DNA Repair (Amst). 2024 Aug;140:103700. doi: 10.1016/j.dnarep.2024.103700. Epub 2024 Jun 4. DNA Repair (Amst). 2024. PMID: 38897003 Free article.