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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Ting PY, Borikar S, Kerrigan JR, Thomsen NM, Aghania E, Hinman AE, Reyes A, Pizzato N, Fodor BD, Wu F, Belew MS, Mao X, Wang J, Chitnis S, Niu W, Hachey A, Cobb JS, Savage NA, Burke A, Paulk J, Dovala D, Lin J, Clifton MC, Ornelas E, Ma X, Ware NF, Sanchez CC, Taraszka J, Terranova R, Knehr J, Altorfer M, Barnes SW, Beckwith REJ, Solomon JM, Dales NA, Patterson AW, Wagner J, Bouwmeester T, Dranoff G, Stevenson SC, Bradner JE. Ting PY, et al. Among authors: burke a. Science. 2024 Jul 5;385(6704):91-99. doi: 10.1126/science.adk6129. Epub 2024 Jul 4. Science. 2024. PMID: 38963839
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J. Bussiere DE, et al. Among authors: burke a. Nat Chem Biol. 2020 Jan;16(1):15-23. doi: 10.1038/s41589-019-0411-6. Epub 2019 Dec 9. Nat Chem Biol. 2020. PMID: 31819272
Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J. Bussiere DE, et al. Among authors: burke a. Nat Chem Biol. 2020 Mar;16(3):361. doi: 10.1038/s41589-020-0471-7. Nat Chem Biol. 2020. PMID: 31942047
A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner.
Sylvain A, Stoehr N, Ma F, Cernijenko A, Schröder M, Khoshouei M, Vogelsanger M, Schoenboerner M, Burke A, Rao P, Solomon JM, Paulk J, Xu L, Dawson J, Begue D, Lefeuvre P, Ahrne E, Hofmann A, Dickson CJ, Arabin P, Zimmerlin A, Kiffe M, Froehlicher M, Boersig T, Elhajouji A, Brichet M, Menon S, Liu S, Mueller M, Wartchow CA, Lin J, Gloria YC, Dickhöfer S, Weber ANR, Welzel T, Kuemmerle-Deschner J, Farady CJ, Pulz R, Bornancin F, Buckley DL, Bassi ZI. Sylvain A, et al. Among authors: burke a. Cell Chem Biol. 2025 Jul 7:S2451-9456(25)00200-4. doi: 10.1016/j.chembiol.2025.06.005. Online ahead of print. Cell Chem Biol. 2025. PMID: 40639372
Ethnicity and childhood cancer survival.
Bate J, Ranasinghe N, Patel G, Feltbower RG; Childhood Haematology and Oncology Research on Disparities Group (CHORD). Bate J, et al. BMJ. 2025 Jul 3;390:r1350. doi: 10.1136/bmj.r1350. BMJ. 2025. PMID: 40610032 No abstract available.
1,815 results