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Page 1
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Ting PY, Borikar S, Kerrigan JR, Thomsen NM, Aghania E, Hinman AE, Reyes A, Pizzato N, Fodor BD, Wu F, Belew MS, Mao X, Wang J, Chitnis S, Niu W, Hachey A, Cobb JS, Savage NA, Burke A, Paulk J, Dovala D, Lin J, Clifton MC, Ornelas E, Ma X, Ware NF, Sanchez CC, Taraszka J, Terranova R, Knehr J, Altorfer M, Barnes SW, Beckwith REJ, Solomon JM, Dales NA, Patterson AW, Wagner J, Bouwmeester T, Dranoff G, Stevenson SC, Bradner JE. Ting PY, et al. Among authors: ornelas e. Science. 2024 Jul 5;385(6704):91-99. doi: 10.1126/science.adk6129. Epub 2024 Jul 4. Science. 2024. PMID: 38963839
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Bonazzi S, d'Hennezel E, Beckwith REJ, Xu L, Fazal A, Magracheva A, Ramesh R, Cernijenko A, Antonakos B, Bhang HC, Caro RG, Cobb JS, Ornelas E, Ma X, Wartchow CA, Clifton MC, Forseth RR, Fortnam BH, Lu H, Csibi A, Tullai J, Carbonneau S, Thomsen NM, Larrow J, Chie-Leon B, Hainzl D, Gu Y, Lu D, Meyer MJ, Alexander D, Kinyamu-Akunda J, Sabatos-Peyton CA, Dales NA, Zécri FJ, Jain RK, Shulok J, Wang YK, Briner K, Porter JA, Tallarico JA, Engelman JA, Dranoff G, Bradner JE, Visser M, Solomon JM. Bonazzi S, et al. Among authors: ornelas e. Cell Chem Biol. 2023 Mar 16;30(3):235-247.e12. doi: 10.1016/j.chembiol.2023.02.005. Epub 2023 Mar 1. Cell Chem Biol. 2023. PMID: 36863346 Free article.
Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease.
Kerrigan JR, Thomsen NM, Cernijenko A, Kochanek SE, Dewhurst J, O'Brien G, Ware NF, Sanchez CC, Manning JR, Ma X, Ornelas E, Savage NA, Partridge JR, Patterson AW, Lam P, Dales NA, Bonazzi S, Borikar S, Hinman AE, Ting PY. Kerrigan JR, et al. Among authors: ornelas e. J Med Chem. 2024 Nov 28;67(22):20682-20694. doi: 10.1021/acs.jmedchem.4c02251. Epub 2024 Nov 14. J Med Chem. 2024. PMID: 39541509
Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness.
Barkan DT, Garland K, Zhang L, Eastman RT, Hesse M, Knapp M, Ornelas E, Tang J, Cortopassi WA, Wang Y, King F, Jia W, Nguyen Z, Frank AO, Chan R, Fang E, Fuller D, Busby S, Carias H, Donahue K, Tandeske L, Diagana TT, Jarrousse N, Moser H, Sarko C, Dovala D, Moquin S, Marx VM. Barkan DT, et al. Among authors: ornelas e. J Med Chem. 2024 Oct 10;67(19):17454-17471. doi: 10.1021/acs.jmedchem.4c01404. Epub 2024 Sep 27. J Med Chem. 2024. PMID: 39332817 Free PMC article.
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation.
Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ, Nomura DK. Spradlin JN, et al. Among authors: ornelas e. Nat Chem Biol. 2019 Jul;15(7):747-755. doi: 10.1038/s41589-019-0304-8. Epub 2019 Jun 17. Nat Chem Biol. 2019. PMID: 31209351 Free PMC article.
Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.
Han W, Ma X, Balibar CJ, Baxter Rath CM, Benton B, Bermingham A, Casey F, Chie-Leon B, Cho MK, Frank AO, Frommlet A, Ho CM, Lee PS, Li M, Lingel A, Ma S, Merritt H, Ornelas E, De Pascale G, Prathapam R, Prosen KR, Rasper D, Ruzin A, Sawyer WS, Shaul J, Shen X, Shia S, Steffek M, Subramanian S, Vo J, Wang F, Wartchow C, Uehara T. Han W, et al. Among authors: ornelas e. J Am Chem Soc. 2020 Mar 4;142(9):4445-4455. doi: 10.1021/jacs.9b13530. Epub 2020 Feb 17. J Am Chem Soc. 2020. PMID: 32064871
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors.
Saldivia M, Fang E, Ma X, Myburgh E, Carnielli JBT, Bower-Lepts C, Brown E, Ritchie R, Lakshminarayana SB, Chen YL, Patra D, Ornelas E, Koh HXY, Williams SL, Supek F, Paape D, McCulloch R, Kaiser M, Barrett MP, Jiricek J, Diagana TT, Mottram JC, Rao SPS. Saldivia M, et al. Among authors: ornelas e. Nat Microbiol. 2020 Oct;5(10):1207-1216. doi: 10.1038/s41564-020-0745-6. Epub 2020 Jul 13. Nat Microbiol. 2020. PMID: 32661312 Free PMC article.
32 results