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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Ting PY, Borikar S, Kerrigan JR, Thomsen NM, Aghania E, Hinman AE, Reyes A, Pizzato N, Fodor BD, Wu F, Belew MS, Mao X, Wang J, Chitnis S, Niu W, Hachey A, Cobb JS, Savage NA, Burke A, Paulk J, Dovala D, Lin J, Clifton MC, Ornelas E, Ma X, Ware NF, Sanchez CC, Taraszka J, Terranova R, Knehr J, Altorfer M, Barnes SW, Beckwith REJ, Solomon JM, Dales NA, Patterson AW, Wagner J, Bouwmeester T, Dranoff G, Stevenson SC, Bradner JE. Ting PY, et al. Among authors: savage na. Science. 2024 Jul 5;385(6704):91-99. doi: 10.1126/science.adk6129. Epub 2024 Jul 4. Science. 2024. PMID: 38963839
Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease.
Kerrigan JR, Thomsen NM, Cernijenko A, Kochanek SE, Dewhurst J, O'Brien G, Ware NF, Sanchez CC, Manning JR, Ma X, Ornelas E, Savage NA, Partridge JR, Patterson AW, Lam P, Dales NA, Bonazzi S, Borikar S, Hinman AE, Ting PY. Kerrigan JR, et al. Among authors: savage na. J Med Chem. 2024 Nov 28;67(22):20682-20694. doi: 10.1021/acs.jmedchem.4c02251. Epub 2024 Nov 14. J Med Chem. 2024. PMID: 39541509
Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8.
Remillard D, Savage NA, Kedves AT, Paulk J, Chen X, Garcia FJ, Romanowski MJ, Horton PA, Murphy J, Schirle M, Harrington EM, Maxwell MB, Pham HT, Maksimovic I, Thomas JR, Forrester WC. Remillard D, et al. Among authors: savage na. ACS Chem Biol. 2021 Nov 19;16(11):2185-2192. doi: 10.1021/acschembio.1c00256. Epub 2021 Sep 13. ACS Chem Biol. 2021. PMID: 34515462