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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response.
Wofford W, Kim J, Kim D, Janneh AH, Lee HG, Atilgan FC, Oleinik N, Kassir MF, Saatci O, Chakraborty P, Tokat UM, Gencer S, Howley B, Howe P, Mehrotra S, Sahin O, Ogretmen B. Wofford W, et al. Among authors: sahin o. Cell Rep. 2024 Aug 27;43(8):114532. doi: 10.1016/j.celrep.2024.114532. Epub 2024 Jul 23. Cell Rep. 2024. PMID: 39046874 Free PMC article.
Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.
Janneh AH, Kassir MF, Atilgan FC, Lee HG, Sheridan M, Oleinik N, Szulc Z, Voelkel-Johnson C, Nguyen H, Li H, Peterson YK, Marangoni E, Saatci O, Sahin O, Lilly M, Atkinson C, Tomlinson S, Mehrotra S, Ogretmen B. Janneh AH, et al. Among authors: sahin o. Cell Rep. 2022 Dec 6;41(10):111742. doi: 10.1016/j.celrep.2022.111742. Cell Rep. 2022. PMID: 36476873 Free PMC article.
HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer.
Ferretti GDS, Quaas CE, Bertolini I, Zuccotti A, Saatci O, Kashatus JA, Sharmin S, Lu DY, Poli ANR, Quesnelle AF, Rodriguez-Blanco J, de Cubas AA, Hobbs GA, Liu Q, O'Bryan JP, Salvino JM, Kashatus DF, Sahin O, Barnoud T. Ferretti GDS, et al. Among authors: o bryan jp, sahin o. Cell Death Differ. 2024 Jul;31(7):881-896. doi: 10.1038/s41418-024-01310-9. Epub 2024 May 28. Cell Death Differ. 2024. PMID: 38802657 Free PMC article.
A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer.
Cetin M, Saatci O, Rezaeian AH, Rao CN, Beneker C, Sreenivas K, Taylor H, Pederson B, Chatzistamou I, Buckley B, Lessner S, Angel P, McInnes C, Sahin O. Cetin M, et al. Among authors: sahin o. Cell Chem Biol. 2024 Nov 21;31(11):1926-1941.e11. doi: 10.1016/j.chembiol.2024.06.012. Epub 2024 Jul 22. Cell Chem Biol. 2024. PMID: 39043186 Free article.
Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer.
Schwab A, Siddiqui MA, Ramesh V, Gollavilli PN, Turtos AM, Møller SS, Pinna L, Havelund JF, Rømer AMA, Ersan PG, Parma B, Marschall S, Dettmer K, Alhusayan M, Bertoglio P, Querzoli G, Mielenz D, Sahin O, Færgeman NJ, Asangani IA, Ceppi P. Schwab A, et al. Among authors: sahin o. Cell Death Differ. 2025 Apr;32(4):587-597. doi: 10.1038/s41418-024-01415-1. Epub 2024 Nov 20. Cell Death Differ. 2025. PMID: 39567724 Free PMC article.
910 results