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Page 1
H1-0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape in preleukemia and B cell acute lymphoblastic leukemia.
Jepsen VH, Hanel A, Picard D, Bhave R, Hasselmann R, Mehtonen J, Schliehe-Diecks J, Kath CJ, Suppiyar V, Prasad Y, Schaal K, Tu JW, Rüchel N, Kameri E, Qin N, Wang H, Zhuang Z, Wagener R, Blümel L, Lautwein T, Hein D, Koppstein D, Kögler G, Remke M, Bhatia S, Heinäniemi M, Borkhardt A, Fischer U. Jepsen VH, et al. Among authors: schliehe diecks j. Hemasphere. 2025 Apr 2;9(4):e70116. doi: 10.1002/hem3.70116. eCollection 2025 Apr. Hemasphere. 2025. PMID: 40177616 Free PMC article.
Deciphering the Therapeutic Potential of Novel Pentyloxyamide-Based Class I, IIb HDAC Inhibitors against Therapy-Resistant Leukemia.
Fischer F, Schliehe-Diecks J, Tu JW, Gangnus T, Ho YL, Hebeis M, Alves Avelar LA, Scharov K, Watrin T, Kemkes M, Stachura P, Daugs K, Biermann L, Kremeyer J, Horstick N, Span I, Pandyra AA, Borkhardt A, Gohlke H, Kassack MU, Burckhardt BB, Bhatia S, Kurz T. Fischer F, et al. Among authors: schliehe diecks j. J Med Chem. 2024 Dec 12;67(23):21223-21250. doi: 10.1021/acs.jmedchem.4c02024. Epub 2024 Nov 27. J Med Chem. 2024. PMID: 39602240
Synergistic drug interactions of the histone deacetylase inhibitor givinostat (ITF2357) in CRLF2-rearranged pediatric B-cell precursor acute lymphoblastic leukemia identified by high-throughput drug screening.
Oikonomou A, Watrin T, Valsecchi L, Scharov K, Savino AM, Schliehe-Diecks J, Bardini M, Fazio G, Bresolin S, Biondi A, Borkhardt A, Bhatia S, Cazzaniga G, Palmi C. Oikonomou A, et al. Among authors: schliehe diecks j. Heliyon. 2024 Jul 3;10(13):e34033. doi: 10.1016/j.heliyon.2024.e34033. eCollection 2024 Jul 15. Heliyon. 2024. PMID: 39071567 Free PMC article.
A brain organoid/ALL coculture model reveals the AP-1 pathway as critically associated with CNS involvement of BCP-ALL.
Gebing P, Loizou S, Hänsch S, Schliehe-Diecks J, Spory L, Stachura P, Jepsen VH, Vogt M, Pandyra AA, Wang H, Zhuang Z, Zimmermann J, Schrappe M, Cario G, Alsadeq A, Schewe DM, Borkhardt A, Lenk L, Fischer U, Bhatia S. Gebing P, et al. Among authors: schliehe diecks j. Blood Adv. 2024 Oct 8;8(19):4997-5011. doi: 10.1182/bloodadvances.2023011145. Blood Adv. 2024. PMID: 39008716 Free PMC article.
Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia.
Blumel L, Bernardi F, Picard D, Diaz JT, Jepsen VH, Hasselmann R, Schliehe-Diecks J, Bartl J, Qin N, Bornhauser B, Bhatia S, Marovka B, Marsaud V, Dingli F, Loew D, Stanulla M, Bourqin JP, Borkhardt A, Remke M, Ayrault O, Fischer U. Blumel L, et al. Among authors: schliehe diecks j. Haematologica. 2024 Jul 1;109(7):2290-2296. doi: 10.3324/haematol.2023.283928. Haematologica. 2024. PMID: 38426288 Free PMC article. No abstract available.
Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells.
Vogt M, Dienstbier N, Schliehe-Diecks J, Scharov K, Tu JW, Gebing P, Hogenkamp J, Bilen BS, Furlan S, Picard D, Remke M, Yasin L, Bickel D, Kalia M, Iacoangeli A, Lenz T, Stühler K, Pandyra AA, Hauer J, Fischer U, Wagener R, Borkhardt A, Bhatia S. Vogt M, et al. Among authors: schliehe diecks j. Cell Death Dis. 2023 Dec 6;14(12):799. doi: 10.1038/s41419-023-06337-3. Cell Death Dis. 2023. PMID: 38057328 Free PMC article.
Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity.
Sinatra L, Yang J, Schliehe-Diecks J, Dienstbier N, Vogt M, Gebing P, Bachmann LM, Sönnichsen M, Lenz T, Stühler K, Schöler A, Borkhardt A, Bhatia S, Hansen FK. Sinatra L, et al. Among authors: schliehe diecks j. J Med Chem. 2022 Dec 22;65(24):16860-16878. doi: 10.1021/acs.jmedchem.2c01659. Epub 2022 Dec 6. J Med Chem. 2022. PMID: 36473103
Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.
Reßing N, Schliehe-Diecks J, Watson PR, Sönnichsen M, Cragin AD, Schöler A, Yang J, Schäker-Hübner L, Borkhardt A, Christianson DW, Bhatia S, Hansen FK. Reßing N, et al. Among authors: schliehe diecks j. J Med Chem. 2022 Nov 24;65(22):15457-15472. doi: 10.1021/acs.jmedchem.2c01418. Epub 2022 Nov 9. J Med Chem. 2022. PMID: 36351184 Free PMC article.
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert AS, Stühler K, Proksch P, Stork B, Wesselborg S. Stuhldreier F, et al. Among authors: schliehe diecks j. Cell Death Dis. 2022 Nov 8;13(11):938. doi: 10.1038/s41419-022-05356-w. Cell Death Dis. 2022. PMID: 36347842 Free PMC article.
18 results