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Cardiovascular toxicities of immune therapies for cancer - a scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Council of Cardio-Oncology.
Tocchetti CG, Farmakis D, Koop Y, Andres MS, Couch LS, Formisano L, Ciardiello F, Pane F, Au L, Emmerich M, Plummer C, Gulati G, Ramalingam S, Cardinale D, Brezden-Masley C, Iakobishvili Z, Thavendiranathan P, Santoro C, Bergler-Klein J, Keramida K, de Boer RA, Maack C, Lutgens E, Rassaf T, Fradley MG, Moslehi J, Yang EH, De Keulenaer G, Ameri P, Bax J, Neilan TG, Herrmann J, Mbakwem AC, Mirabel M, Skouri H, Hirsch E, Cohen-Solal A, Sverdlov AL, van der Meer P, Asteggiano R, Barac A, Ky B, Lenihan D, Dent S, Seferovic P, Coats AJS, Metra M, Rosano G, Suter T, Lopez-Fernandez T, Lyon AR. Tocchetti CG, et al. Among authors: lutgens e. Eur J Heart Fail. 2024 Oct;26(10):2055-2076. doi: 10.1002/ejhf.3340. Epub 2024 Aug 1. Eur J Heart Fail. 2024. PMID: 39087551 Free article. Review.
Roadmap for alleviating the manifestations of ageing in the cardiovascular system.
Liberale L, Tual-Chalot S, Sedej S, Ministrini S, Georgiopoulos G, Grunewald M, Bäck M, Bochaton-Piallat ML, Boon RA, Ramos GC, de Winther MPJ, Drosatos K, Evans PC, Ferguson JF, Forslund-Startceva SK, Goettsch C, Giacca M, Haendeler J, Kallikourdis M, Ketelhuth DFJ, Koenen RR, Lacolley P, Lutgens E, Maffia P, Miwa S, Monaco C, Montecucco F, Norata GD, Osto E, Richardson GD, Riksen NP, Soehnlein O, Spyridopoulos I, Van Linthout S, Vilahur G, Wentzel JJ, Andrés V, Badimon L, Benetos A, Binder CJ, Brandes RP, Crea F, Furman D, Gorbunova V, Guzik TJ, Hill JA, Lüscher TF, Mittelbrunn M, Nencioni A, Netea MG, Passos JF, Stamatelopoulos KS, Tavernarakis N, Ungvari Z, Wu JC, Kirkland JL, Camici GG, Dimmeler S, Kroemer G, Abdellatif M, Stellos K. Liberale L, et al. Among authors: lutgens e. Nat Rev Cardiol. 2025 Feb 19. doi: 10.1038/s41569-025-01130-5. Online ahead of print. Nat Rev Cardiol. 2025. PMID: 39972009 Review.
Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis increasing the risk of cerebrovascular complications.
Dib L, Koneva LA, Edsfeldt A, Zurke YX, Sun J, Nitulescu M, Attar M, Lutgens E, Schmidt S, Lindholm MW, Choudhury RP, Cassimjee I, Lee R, Handa A, Goncalves I, Sansom SN, Monaco C. Dib L, et al. Among authors: lutgens e. Nat Cardiovasc Res. 2023 Jun 26;2(7):656-672. doi: 10.1038/s44161-023-00295-x. Nat Cardiovasc Res. 2023. PMID: 38362263 Free PMC article.
Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification.
Pavlic A, Poelman H, Wasilewski G, Wichapong K, Lux P, Maassen C, Lutgens E, Schurgers LJ, Reutelingsperger CP, Nicolaes GAF. Pavlic A, et al. Among authors: lutgens e. Int J Mol Sci. 2023 Jan 19;24(3):2027. doi: 10.3390/ijms24032027. Int J Mol Sci. 2023. PMID: 36768348 Free PMC article.
CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension.
Strohm L, Ubbens H, Mihalikova D, Czarnowski A, Stamm P, Molitor M, Finger S, Oelze M, Atzler D, Wenzel P, Lurz P, Münzel T, Weber C, Lutgens E, Daiber A, Daub S. Strohm L, et al. Among authors: lutgens e. Redox Biol. 2025 Mar;80:103520. doi: 10.1016/j.redox.2025.103520. Epub 2025 Jan 29. Redox Biol. 2025. PMID: 39899926 Free PMC article.
Immunotherapy for atherosclerosis.
Monaco C, McNamara CA, Slütter B, Foks AC, Bekiranov S, Mulder WJM, Goncalves I, Lutgens E; LeDucq International Network of Excellence on Immune Checkpoints in Atherosclerosis: “CHECKPOINT ATHERO”. Monaco C, et al. Among authors: lutgens e. Physiol Rev. 2025 Oct 1;105(4):2141-2230. doi: 10.1152/physrev.00016.2024. Epub 2025 May 21. Physiol Rev. 2025. PMID: 40397615 Review.
254 results