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Page 1
Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination.
Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, Ippolito GC. Voss WN, et al. Among authors: mclellan js. Cell Rep Med. 2024 Aug 20;5(8):101668. doi: 10.1016/j.xcrm.2024.101668. Epub 2024 Aug 1. Cell Rep Med. 2024. PMID: 39094579 Free PMC article.
Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38.
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS. Shin OS, et al. Among authors: mclellan js. Cell Rep. 2024 Jul 23;43(7):114502. doi: 10.1016/j.celrep.2024.114502. Epub 2024 Jul 13. Cell Rep. 2024. PMID: 39002130 Free PMC article.
A single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein.
Oraby AK, Stojic A, Elawar F, Bilawchuk LM, McClelland RD, Erwin K, Granoski MJ, Griffiths CD, Frederick JD, Arutyunova E, Joanne Lemieux M, West FG, Ramilo O, Mejias A, McLellan JS, Marchant DJ. Oraby AK, et al. Among authors: mclellan js. Npj Viruses. 2025 Apr 22;3(1):33. doi: 10.1038/s44298-025-00119-8. Npj Viruses. 2025. PMID: 40295799 Free PMC article.
Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer.
Zehner M, Alt M, Ashurov A, Goldsmith JA, Spies R, Weiler N, Lerma J, Gieselmann L, Stöhr D, Gruell H, Schultz EP, Kreer C, Schlachter L, Janicki H, Laib Sampaio K, Stegmann C, Nemetchek MD, Dähling S, Ullrich L, Dittmer U, Witzke O, Koch M, Ryckman BJ, Lotfi R, McLellan JS, Krawczyk A, Sinzger C, Klein F. Zehner M, et al. Among authors: mclellan js. Immunity. 2023 Nov 14;56(11):2602-2620.e10. doi: 10.1016/j.immuni.2023.10.009. Immunity. 2023. PMID: 37967532 Free article.
A conserved tryptophan in the acylated segment of RTX toxins controls their β2 integrin-independent cell penetration.
Osickova A, Knoblochova S, Bumba L, Man P, Kalaninova Z, Lepesheva A, Jurnecka D, Cizkova M, Biedermannova L, Goldsmith JA, Maynard JA, McLellan JS, Osicka R, Sebo P, Masin J. Osickova A, et al. Among authors: mclellan js. J Biol Chem. 2023 Aug;299(8):104978. doi: 10.1016/j.jbc.2023.104978. Epub 2023 Jun 28. J Biol Chem. 2023. PMID: 37390987 Free PMC article.
A human cytomegalovirus prefusion-like glycoprotein B subunit vaccine elicits humoral immunity similar to that of postfusion gB in mice.
Karthigeyan KP, Connors M, Binuya CR, Gross M, Fuller AS, Crooks CM, Wang H-Y, Sponholtz MR, Byrne PO, Herbek S, Andy C, Gerber LM, Campbell JD, Williams CA, Mitchell E, van der Maas L, Miller I, Yu D, Bottomley MJ, McLellan JS, Permar SR. Karthigeyan KP, et al. Among authors: mclellan js. J Virol. 2025 Jun 17;99(6):e0217824. doi: 10.1128/jvi.02178-24. Epub 2025 May 8. J Virol. 2025. PMID: 40338082 Free PMC article.
Structural basis for neutralizing antibody binding to pertussis toxin.
Goldsmith JA, Nguyen AW, Wilen RE, Wijagkanalan W, McLellan JS, Maynard JA. Goldsmith JA, et al. Among authors: mclellan js. Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2419457122. doi: 10.1073/pnas.2419457122. Epub 2025 Apr 2. Proc Natl Acad Sci U S A. 2025. PMID: 40172968
224 results