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Phase 1 study of NEDD8 activating enzyme inhibitor pevonedistat in combination with chemotherapy in pediatric patients with recurrent or refractory solid tumors (ADVL1615).
Foster JH, Reid JM, Minard C, Woodfield S, Denic KZ, Isikwei E, Voss SD, Nelson M, Liu X, Berg SL, Fox E, Weigel BJ. Foster JH, et al. Among authors: isikwei e. Eur J Cancer. 2024 Sep;209:114241. doi: 10.1016/j.ejca.2024.114241. Epub 2024 Aug 2. Eur J Cancer. 2024. PMID: 39096851 Clinical Trial.
A phase 1 trial utilizing a pharmacokinetic endpoint to determine the optimal dose of ramucirumab in children and adolescents with relapsed or refractory solid tumors, including central nervous system tumors.
Pilbeam KL, Pradhan K, Croop J, Minard CG, Liu X, Voss SD, Isikwei E, Berg SL, Reid JM, Fox E, Weigel BJ. Pilbeam KL, et al. Among authors: isikwei e. Pediatr Blood Cancer. 2024 Mar;71(3):e30817. doi: 10.1002/pbc.30817. Epub 2024 Jan 8. Pediatr Blood Cancer. 2024. PMID: 38189770 Free PMC article. Clinical Trial.
FDA Approval Summary: Cabozantinib for Differentiated Thyroid Cancer.
Duke ES, Barone AK, Chatterjee S, Mishra-Kalyani PS, Shen YL, Isikwei E, Zhao H, Bi Y, Liu J, Rahman NA, Wearne E, Leighton JK, Stephenson M, Ojofeitimi I, Scepura B, Nair A, Pazdur R, Beaver JA, Singh H. Duke ES, et al. Among authors: isikwei e. Clin Cancer Res. 2022 Oct 3;28(19):4173-4177. doi: 10.1158/1078-0432.CCR-22-0873. Clin Cancer Res. 2022. PMID: 35679021 Free PMC article. Clinical Trial.