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P2X7 receptors exhibit at least three modes of allosteric antagonism.
Sci Adv. 2024 Oct 4;10(40):eado5084. doi: 10.1126/sciadv.ado5084. Epub 2024 Oct 4.
Sci Adv. 2024.
PMID: 39365862
Free PMC article.
High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket.
Oken AC, Lisi NE, Krishnamurthy I, McCarthy AE, Godsey MH, Glasfeld A, Mansoor SE.
Oken AC, et al. Among authors: krishnamurthy i.
Nat Commun. 2024 Aug 6;15(1):6662. doi: 10.1038/s41467-024-50771-6.
Nat Commun. 2024.
PMID: 39107314
Free PMC article.
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Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology.
Oken AC, Krishnamurthy I, Savage JC, Lisi NE, Godsey MH, Mansoor SE.
Oken AC, et al. Among authors: krishnamurthy i.
Front Pharmacol. 2022 Jun 17;13:925880. doi: 10.3389/fphar.2022.925880. eCollection 2022.
Front Pharmacol. 2022.
PMID: 35784697
Free PMC article.
Review.
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The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner.
O'Connell ME, Sridharan D, Driscoll T, Krishnamurthy I, Perry WG, Applewhite DA.
O'Connell ME, et al. Among authors: krishnamurthy i.
Biol Open. 2019 Jun 17;8(6):bio038232. doi: 10.1242/bio.038232.
Biol Open. 2019.
PMID: 31164339
Free PMC article.
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