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Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.
Aebi J, Atz K, Ametamey SM, Benz J, Blaising J, Butini S, Campiani G, Carreira EM, Collin L, De Lago E, Gazzi T, Gertsch J, Gobbi L, Guba W, Fernández-Ruiz J, Fingerle J, Haider A, He Y, Heitman LH, Honer M, Hunziker D, Kuhn B, Maccarrone M, Märki HP, Martin RE, Mohr P, Mu L, Nazaré M, Nippa DF, Oddi S, O'Hara F, Pacher P, Romero J, Röver S, Rufer AC, Schibli R, Schneider G, Stepan AF, Sykes DA, Ullmer C, Van der Stelt M, Veprintsev DB, Wittwer MB, Grether U. Aebi J, et al. Among authors: veprintsev db. Chimia (Aarau). 2024 Aug 21;78(7-8):499-512. doi: 10.2533/chimia.2024.499. Chimia (Aarau). 2024. PMID: 39221845 Free article.
Visualization of membrane localization and the functional state of CB2R pools using matched agonist and inverse agonist probe pairs.
Wąsińska-Kałwa M, Omran A, Mach L, Scipioni L, Bouma J, Li X, Radetzki S, Mostinski Y, Schippers M, Gazzi T, van der Horst C, Brennecke B, Hanske A, Kolomeets Y, Guba W, Sykes D, von Kries JP, Broichhagen J, Hua T, Veprintsev D, Heitman LH, Oddi S, Maccarrone M, Grether U, Nazare M. Wąsińska-Kałwa M, et al. Chem Sci. 2024 Oct 3;15(44):18443-54. doi: 10.1039/d4sc00402g. Online ahead of print. Chem Sci. 2024. PMID: 39430942 Free PMC article.
Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe.
Kosar M, Perera T, Ganzoni RLZ, Sarott RC, Borrega-Roman L, Vitale RM, Ligresti A, Rufer AC, Guba W, Grether U, Carreira EM, Veprintsev DB, Sykes DA. Kosar M, et al. Among authors: veprintsev db. Angew Chem Int Ed Engl. 2025 May 12;64(20):e202421885. doi: 10.1002/anie.202421885. Epub 2025 Apr 1. Angew Chem Int Ed Engl. 2025. PMID: 39963774
A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay.
Borrega-Roman L, Hoare BL, Kosar M, Sarott RC, Patej KJ, Bouma J, Scott-Dennis M, Koers EJ, Gazzi T, Mach L, Barrondo S, Sallés J, Guba W, Kusznir E, Nazaré M, Rufer AC, Grether U, Heitman LH, Carreira EM, Sykes DA, Veprintsev DB. Borrega-Roman L, et al. Among authors: veprintsev db. Front Pharmacol. 2025 Apr 9;16:1469986. doi: 10.3389/fphar.2025.1469986. eCollection 2025. Front Pharmacol. 2025. PMID: 40271066 Free PMC article.
Advancing research on regulatory autoantibodies targeting GPCRs: Insights from the 5th international symposium.
Cabral-Marques O, Schimke LF, Moll G, Filgueiras IS, Nóbile AL, Adri AS, do Vale FYN, Usuda JN, Corrêa YLG, Albuquerque D, Nava RG, Santos RS, Dias HD, Silva HF, Marconi PB, Catar R, Adu-Gyamfi M, Wang P, Khan TA, Hackel AM, Leheis A, Stähle A, Müller A, Schmidt C, Radunovic C, Adjailia EB, Grasshoff H, Humrich JY, Menz J, Fourlakis K, Winziers M, Jäpel M, Wegner MV, Lamprecht P, Nieberding R, Akbarzadeh R, Arnold S, Jendrek S, Klapa S, Augustin S, Biedermann S, Schinke S, Scheerer P, Endres M, Schulze-Forster K, Paul F, Yu X, Sotzny F, Sakmar TP, Banasik M, Haghikia A, Hoffmann MH, Veprintsev D, Witte T, Dalmolin RJS, Ochs HD, Heidecke H, Scheibenbogen C, Shoenfeld Y, Riemekasten G. Cabral-Marques O, et al. Autoimmun Rev. 2025 Jun 19;24(9):103855. doi: 10.1016/j.autrev.2025.103855. Online ahead of print. Autoimmun Rev. 2025. PMID: 40543860 Free article. Review.
95 results