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Neo-adjuvant pembrolizumab in stage IV high-grade serous ovarian cancer: the phase II Neo-Pembro trial.
Aronson SL, Thijssen B, Lopez-Yurda M, Koole SN, van der Leest P, León-Castillo A, Harkes R, Seignette IM, Sanders J, Alkemade M, Kemper I, Holtkamp MJ, Mandjes IAM, Broeks A, Lahaye MJ, Rijlaarsdam MA, van den Broek D, Wessels LFA, Horlings HM, van Driel WJ, Sonke GS. Aronson SL, et al. Among authors: harkes r. Nat Commun. 2025 Apr 14;16(1):3520. doi: 10.1038/s41467-025-58440-y. Nat Commun. 2025. PMID: 40229272 Free PMC article. Clinical Trial.
A novel lineage-tracing tool reveals that hypoxic tumor cells drive tumor relapse after radiotherapy.
Menegakis A, Vennin C, Ient J, Groot AJ, Krenning L, Klompmaker R, Friskes A, Ilic M, Yaromina A, Harkes R, van den Broek B, Jakob Sonke J, De Jong M, Piepers J, van Rheenen J, Vooijs MA, Medema RH. Menegakis A, et al. Among authors: harkes r. Radiother Oncol. 2025 Jan;202:110592. doi: 10.1016/j.radonc.2024.110592. Epub 2024 Oct 18. Radiother Oncol. 2025. PMID: 39427933 Free PMC article.
Mechanisms that clear mutations drive field cancerization in mammary tissue.
Ciwinska M, Messal HA, Hristova HR, Lutz C, Bornes L, Chalkiadakis T, Harkes R, Langedijk NSM, Hutten SJ, Menezes RX, Jonkers J, Prekovic S; Grand Challenge PRECISION consortium; Simons BD, Scheele CLGJ, van Rheenen J. Ciwinska M, et al. Among authors: harkes r. Nature. 2024 Sep;633(8028):198-206. doi: 10.1038/s41586-024-07882-3. Epub 2024 Sep 4. Nature. 2024. PMID: 39232148 Free PMC article.
IHC-based Ki67 as response biomarker to tamoxifen in breast cancer window trials enrolling premenopausal women.
Joosten SEP, Wellenstein M, Koornstra R, van Rossum A, Sanders J, van der Noort V, Ferrandez MC, Harkes R, Mandjes IAM, Rosing H, Huitema A, Beijnen JH, Wesseling J, van Diest PJ, Horlings HM, Linn SC, Zwart W. Joosten SEP, et al. Among authors: harkes r. NPJ Breast Cancer. 2021 Oct 20;7(1):138. doi: 10.1038/s41523-021-00344-3. NPJ Breast Cancer. 2021. PMID: 34671036 Free PMC article.
17 results