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Page 1
Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations.
McCoull W, Thomson C, Braybrooke E, Chan C, Colclough N, Cortés González MA, Cosulich S, Davies NL, Floc'h N, Greenwood R, Hargreaves D, Huang P, Hunt TA, Johnson T, Johnström P, Kettle JG, Kondrashov M, Kostomiris DH, Li S, Lister A, Martin S, McKerrecher D, McLean N, Nissink JWM, Orme JP, Orwig P, Packer MJ, Pearson S, Qin L, Felisberto-Rodrigues C, Savoca A, Schou M, Stokes S, Swaih AM, Talbot S, Tucker MJ, Ward RA, Wadforth E, Wang C, Wilson J, Yang Y. McCoull W, et al. Among authors: floc h n. J Med Chem. 2025 Feb 13;68(3):3700-3748. doi: 10.1021/acs.jmedchem.4c02811. Epub 2025 Jan 27. J Med Chem. 2025. PMID: 39869768
Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Thomson C, Braybrooke E, Colclough N, Davies NL, Floc'h N, Greenwood R, Guérot C, Hargreaves D, Johnstrom P, Khurana P, Kostomiris DH, Li S, Lister A, Lorthioir O, Martin S, McCoull W, McLean NJ, McWilliams L, Orme JP, Packer MJ, Pearson S, Swaih AM, Tentarelli S, Tucker MJ, Ward RA, Wilkinson S, Winlow P, Wood IL. Thomson C, et al. Among authors: floc h n. J Med Chem. 2024 Sep 28. doi: 10.1021/acs.jmedchem.4c01792. Online ahead of print. J Med Chem. 2024. PMID: 39340451
A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer.
de Almeida FN, Vasciaveo A, Antao AM, Zou M, Di Bernardo M, de Brot S, Rodriguez-Calero A, Chui A, Wang ALE, Floc'h N, Kim JY, Afari SN, Mukhammadov T, Arriaga JM, Lu J, Shen MM, Rubin MA, Califano A, Abate-Shen C. de Almeida FN, et al. Among authors: floc h n. bioRxiv [Preprint]. 2024 Aug 26:2024.08.24.609538. doi: 10.1101/2024.08.24.609538. bioRxiv. 2024. PMID: 39253480 Free PMC article. Preprint.
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Thomson C, Barton P, Braybrooke E, Colclough N, Dong Z, Evans L, Floc'h N, Guérot C, Hargreaves D, Khurana P, Li S, Li X, Lister A, McCoull W, McWilliams L, Orme JP, Packer MJ, Swaih AM, Ward RA, Winlow P, Ye Y. Thomson C, et al. Among authors: floc h n. J Med Chem. 2024 Jun 13;67(11):8988-9027. doi: 10.1021/acs.jmedchem.4c00227. Epub 2024 May 21. J Med Chem. 2024. PMID: 38770784
BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.
Bertran-Alamillo J, Giménez-Capitán A, Román R, Talbot S, Whiteley R, Floc'h N, Martínez-Pérez E, Martin MJ, Smith PD, Sullivan I, Terp MG, Saeh J, Marino-Buslje C, Fabbri G, Guo G, Xu M, Tornador C, Aguilar-Hernández A, Reguart N, Ditzel HJ, Martínez-Bueno A, Nabau-Moretó N, Gascó A, Rosell R, Pease JE, Polanska UM, Travers J, Urosevic J, Molina-Vila MA. Bertran-Alamillo J, et al. Among authors: floc h n. Mol Cancer. 2023 Jul 13;22(1):110. doi: 10.1186/s12943-023-01815-w. Mol Cancer. 2023. PMID: 37443114 Free PMC article.
110 results