Stone EM - Search Results

1

MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors.

Chen S, Hou J, Jaffery R, Guerrero A, Fu R, Shi L, Zheng N, Bohat R, Egan NA, Yu C, Sharif S, Lu Y, He W, Wang S, Gjuka D, Stone EM, Shah PA, Rodon Ahnert J, Chen T, Liu X, Bedford MT, Xu H, Peng W. Chen S, et al. Among authors: stone em. J Immunother Cancer. 2024 Sep 23;12(9):e009600. doi: 10.1136/jitc-2024-009600. J Immunother Cancer. 2024. PMID: 39313308 Free PMC article.

2

Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance.

Gjuka D, Adib E, Garrison K, Chen J, Zhang Y, Li W, Boutz D, Lamb C, Tanno Y, Nassar A, El Zarif T, Kale N, Rakaee M, Mouhieddine TH, Alaiwi SA, Gusev A, Rogers T, Gao J, Georgiou G, Kwiatkowski DJ, Stone E. Gjuka D, et al. Cancer Cell. 2023 Oct 9;41(10):1774-1787.e9. doi: 10.1016/j.ccell.2023.09.005. Epub 2023 Sep 28. Cancer Cell. 2023. PMID: 37774699 Free PMC article.

3

Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11.

Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W. Lang X, et al. Among authors: stone em. Cancer Discov. 2019 Dec;9(12):1673-1685. doi: 10.1158/2159-8290.CD-19-0338. Epub 2019 Sep 25. Cancer Discov. 2019. PMID: 31554642 Free PMC article.

4

Cyst(e)inase-Rapamycin Combination Induces Ferroptosis in Both In Vitro and In Vivo Models of Hereditary Leiomyomatosis and Renal Cell Cancer.

Kerimoglu B, Lamb C, McPherson RD, Ergen E, Stone EM, Ooi A. Kerimoglu B, et al. Among authors: stone em. Mol Cancer Ther. 2022 Mar 1;21(3):419-426. doi: 10.1158/1535-7163.MCT-21-0661. Mol Cancer Ther. 2022. PMID: 35086957 Free PMC article.

5

Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition.

Saha A, Zhao S, Kindall A, Wilder C, Friedman CA, Clark R, Georgiou G, Stone E, Kidane D, DiGiovanni J. Saha A, et al. J Exp Clin Cancer Res. 2023 May 11;42(1):119. doi: 10.1186/s13046-023-02677-2. J Exp Clin Cancer Res. 2023. PMID: 37170264 Free PMC article.

6

Enzymatic depletion of l-Met using an engineered human enzyme as a novel therapeutic strategy for melanoma.

Wilder CS, Chiou J, Battenhouse A, Saha A, Chen Z, Kim E, Gadallah MI, Tiziani S, Georgiou G, Stone E, DiGiovanni J. Wilder CS, et al. Mol Carcinog. 2023 Oct;62(10):1531-1545. doi: 10.1002/mc.23597. Epub 2023 Jun 28. Mol Carcinog. 2023. PMID: 37378415

7

Combinatorial Approaches to Enhance DNA Damage following Enzyme-Mediated Depletion of L-Cys for Treatment of Pancreatic Cancer.

Saha A, Zhao S, Chen Z, Georgiou G, Stone E, Kidane D, DiGiovanni J. Saha A, et al. Mol Ther. 2021 Feb 3;29(2):775-787. doi: 10.1016/j.ymthe.2020.10.016. Epub 2020 Oct 20. Mol Ther. 2021. PMID: 33091613 Free PMC article.

8

Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.

Stone EM, Glazer ES, Chantranupong L, Cherukuri P, Breece RM, Tierney DL, Curley SA, Iverson BL, Georgiou G. Stone EM, et al. ACS Chem Biol. 2010 Mar 19;5(3):333-42. doi: 10.1021/cb900267j. ACS Chem Biol. 2010. PMID: 20050660 Free PMC article.

9

Bioengineered human arginase I with enhanced activity and stability controls hepatocellular and pancreatic carcinoma xenografts.

Glazer ES, Stone EM, Zhu C, Massey KL, Hamir AN, Curley SA. Glazer ES, et al. Among authors: stone em. Transl Oncol. 2011 Jun;4(3):138-46. doi: 10.1593/tlo.10265. Epub 2011 Jun 1. Transl Oncol. 2011. PMID: 21633669 Free PMC article.

10

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth.

Cramer SL, Saha A, Liu J, Tadi S, Tiziani S, Yan W, Triplett K, Lamb C, Alters SE, Rowlinson S, Zhang YJ, Keating MJ, Huang P, DiGiovanni J, Georgiou G, Stone E. Cramer SL, et al. Nat Med. 2017 Jan;23(1):120-127. doi: 10.1038/nm.4232. Epub 2016 Nov 21. Nat Med. 2017. PMID: 27869804 Free PMC article.

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