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Olverembatinib combined with venetoclax and reduced-intensity chemotherapy for adult newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia: a single-center, single-arm, phase 2 trial.
Gong X, Liu W, Liu Y, Fang Q, Gu R, Liu K, Lin D, Zhou C, Zhang G, Gong B, Wei S, Li Y, Li S, Wang Y, Hu Y, Qiu S, Liu B, Wang Y, Mi Y, Wei H, Wang J. Gong X, et al. Among authors: lin d. Leukemia. 2025 Jun 30. doi: 10.1038/s41375-025-02674-8. Online ahead of print. Leukemia. 2025. PMID: 40588568
Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A.
Jayashankar V, Kubiniok P, McCracken AN, Gentry RG, Eckenstein KH, Sernissi L, Vece V, Garsi JB, Valles SY, Jung S, Hoffman NC, Perrochon AS, Selwan EM, Finicle BT, Pitman M, Lin D, Bonneil É, Xu R, Mao C, Kaiser P, Fruman DA, Mobley D, Jang C, Hanessian S, Thibault P, Edinger AL. Jayashankar V, et al. Among authors: lin d. EMBO J. 2025 Jun 30. doi: 10.1038/s44318-025-00490-5. Online ahead of print. EMBO J. 2025. PMID: 40588551
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