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Low-dose titrated amitriptyline as second-line treatment for adults with irritable bowel syndrome in primary care: the ATLANTIS RCT.
Wright-Hughes A, Ford AC, Alderson SL, Ow PL, Ridd MJ, Foy R, Bishop FL, Chaddock M, Cook H, Cooper D, Fernandez C, Guthrie EA, Hartley S, Herbert A, Howdon D, Muir DP, Newman S, Taylor CA, Teasdale EJ, Thornton R, Everitt HA, Farrin AJ. Wright-Hughes A, et al. Among authors: muir dp. Health Technol Assess. 2024 Oct;28(66):1-161. doi: 10.3310/BFCR7986. Health Technol Assess. 2024. PMID: 39397570 Free PMC article. Clinical Trial.
Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial.
Ford AC, Wright-Hughes A, Alderson SL, Ow PL, Ridd MJ, Foy R, Bianco G, Bishop FL, Chaddock M, Cook H, Cooper D, Fernandez C, Guthrie EA, Hartley S, Herbert A, Howdon D, Muir DP, Nath T, Newman S, Smith T, Taylor CA, Teasdale EJ, Thornton R, Farrin AJ, Everitt HA; ATLANTIS trialists. Ford AC, et al. Among authors: muir dp. Lancet. 2023 Nov 11;402(10414):1773-1785. doi: 10.1016/S0140-6736(23)01523-4. Epub 2023 Oct 16. Lancet. 2023. PMID: 37858323 Free article. Clinical Trial.
Low-dose amitriptyline for irritable bowel syndrome: a qualitative study of patients' and GPs' views and experiences.
Teasdale EJ, Everitt HA, Alderson SL, Ford AC, Hanney J, Chaddock M, Williamson E, Cook H, Farrin AJ, Fernandez C, Guthrie EA, Hartley S, Herbert A, Howdon D, Muir D, Newman S, Ow PL, Ridd MJ, Taylor CM, Thornton R, Wright-Hughes A, Bishop FL. Teasdale EJ, et al. Br J Gen Pract. 2025 May 29;75(755):e431-e439. doi: 10.3399/BJGP.2024.0303. Print 2025 Jun. Br J Gen Pract. 2025. PMID: 39191441 Free PMC article.
Predictors of response to low-dose amitriptyline for irritable bowel syndrome and efficacy and tolerability according to subtype: post hoc analyses from the ATLANTIS trial.
Wright-Hughes A, Ow PL, Alderson SL, Ridd MJ, Foy R, Bishop FL, Chaddock M, Fernandez C, Guthrie EA, Muir DP, Taylor CA, Farrin AJ, Everitt HA, Ford AC. Wright-Hughes A, et al. Among authors: muir dp. Gut. 2025 Apr 7;74(5):728-739. doi: 10.1136/gutjnl-2024-334490. Gut. 2025. PMID: 39863398 Free PMC article.