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Remyelination protects neurons from DLK-mediated neurodegeneration.
Duncan GJ, Ingram SD, Emberley K, Hill J, Cordano C, Abdelhak A, McCane M, Jenks JE, Jabassini N, Ananth K, Ferrara SJ, Stedelin B, Sivyer B, Aicher SA, Scanlan TS, Watkins TA, Mishra A, Nelson JW, Green AJ, Emery B. Duncan GJ, et al. Among authors: scanlan ts. Nat Commun. 2024 Oct 23;15(1):9148. doi: 10.1038/s41467-024-53429-5. Nat Commun. 2024. PMID: 39443516 Free PMC article.
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration.
Hochbaum DR, Hulshof L, Urke A, Wang W, Dubinsky AC, Farnsworth HC, Hakim R, Lin S, Kleinberg G, Robertson K, Park C, Solberg A, Yang Y, Baynard C, Nadaf NM, Beron CC, Girasole AE, Chantranupong L, Cortopassi MD, Prouty S, Geistlinger L, Banks AS, Scanlan TS, Datta SR, Greenberg ME, Boulting GL, Macosko EZ, Sabatini BL. Hochbaum DR, et al. Among authors: scanlan ts. Cell. 2024 Oct 3;187(20):5679-5697.e23. doi: 10.1016/j.cell.2024.07.041. Epub 2024 Aug 22. Cell. 2024. PMID: 39178853 Free PMC article.
TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor.
Ferrara SJ, Chaudhary P, DeBell MJ, Marracci G, Miller H, Calkins E, Pocius E, Napier BA, Emery B, Bourdette D, Scanlan TS. Ferrara SJ, et al. Among authors: scanlan ts. bioRxiv [Preprint]. 2021 Jan 27:2021.01.25.428149. doi: 10.1101/2021.01.25.428149. bioRxiv. 2021. Update in: Cell Chem Biol. 2022 Feb 17;29(2):239-248.e4. doi: 10.1016/j.chembiol.2021.07.014. PMID: 33532772 Free PMC article. Updated. Preprint.
164 results