Li N - Search Results

1

Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities.

Fu XJ, Huang J, Li N, Liu YH, Liu QG, Yuan S, Xu Y, Chen YF, Zhao YX, Song J, Zhang SY, Bai YR. Fu XJ, et al. Among authors: li n. Eur J Med Chem. 2023 Oct 17;262:115883. doi: 10.1016/j.ejmech.2023.115883. Online ahead of print. Eur J Med Chem. 2023. PMID: 39491429

2

Discovery of Novel N-(5-(Pyridin-3-yl)-1H-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease.

Yang B, Zhang H, Li N, Gao L, Jiang H, Kan W, Yuan H, Li J, Zhao D, Xiong B, Zhou Y, Guo D, Liu T. Yang B, et al. Among authors: li j, li n. J Med Chem. 2022 Dec 8;65(23):15770-15788. doi: 10.1021/acs.jmedchem.2c01334. Epub 2022 Nov 17. J Med Chem. 2022. PMID: 36384292

3

Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]triazoles as potent tubulin polymerization inhibitors.

Li N, Guan Q, Hong Y, Zhang B, Li M, Li X, Li B, Wu L, Zhang W. Li N, et al. Among authors: li x, li m, li b. Eur J Med Chem. 2023 Aug 5;256:115402. doi: 10.1016/j.ejmech.2023.115402. Epub 2023 Apr 23. Eur J Med Chem. 2023. PMID: 37182330

4

Strategies that regulate Hippo signaling pathway for novel anticancer therapeutics.

Li N, Liu YH, Wu J, Liu QG, Niu JB, Zhang Y, Fu XJ, Song J, Zhang SY. Li N, et al. Eur J Med Chem. 2024 Oct 5;276:116694. doi: 10.1016/j.ejmech.2024.116694. Epub 2024 Jul 20. Eur J Med Chem. 2024. PMID: 39047607 Review.

5

Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as potent reversal agents against ABCB1-mediated multidrug resistance.

Fu XJ, Li N, Wu J, Wang ZY, Liu RR, Niu JB, Taleb M, Yuan S, Liu HM, Song J, Zhang SY. Fu XJ, et al. Among authors: li n. Eur J Med Chem. 2024 Nov 5;277:116761. doi: 10.1016/j.ejmech.2024.116761. Epub 2024 Aug 13. Eur J Med Chem. 2024. PMID: 39151276

6

Optimization and Biological Evaluation of Novel 1H-Pyrrolo[2,3-c]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia.

Jiang H, Li C, Li N, Sheng L, Wang J, Kan WJ, Chen Y, Zhao D, Guo D, Zhou YB, Xiong B, Li J, Liu T. Jiang H, et al. Among authors: li c, li j, li n. J Med Chem. 2024 Dec 26;67(24):22080-22103. doi: 10.1021/acs.jmedchem.4c02017. Epub 2024 Dec 4. J Med Chem. 2024. PMID: 39630953

7

Conformational restriction enables discovering a series of chroman derivatives as potent and selective Na_V1.8 inhibitors with improved pharmacokinetic properties.

Li N, Wang L, Hu X, Xu H, Yang B, Zhan L, Cai Y, Gu Y, Chen X, Zheng Y, Liu T, Gao Z, Xiong B. Li N, et al. Eur J Med Chem. 2025 Sep 5;293:117697. doi: 10.1016/j.ejmech.2025.117697. Epub 2025 May 6. Eur J Med Chem. 2025. PMID: 40347793

8

Design, Synthesis, and Biological Evaluation of Selective PAK4 Degrader for the Treatment of Lung Tumor Metastasis.

Wang H, Song P, Wang Y, Xu H, Shen L, Qi Z, Chen L, Ma L, Wang Z, Hu X, Wang W, Li N, Yu Y, Gao Y, Xia M, Zhao D, Wang J, Cheng M. Wang H, et al. Among authors: li n. J Med Chem. 2025 Jun 12;68(11):11231-11269. doi: 10.1021/acs.jmedchem.5c00197. Epub 2025 May 22. J Med Chem. 2025. PMID: 40404481

9

Discovery of new celastrol derivatives with antitumor activity in vitro and invivo by blocking Hsp90-Cdc37-kinase cycle.

Zhang L, Sun J, Wang J, Wang Y, Ju W, Zhang Y, Li N, Chen L. Zhang L, et al. Among authors: li n. Eur J Med Chem. 2025 May 28;296:117827. doi: 10.1016/j.ejmech.2025.117827. Online ahead of print. Eur J Med Chem. 2025. PMID: 40472487

10

Synthesis and identification of azocoumarin derivatives toward imaging of α-synuclein aggregates in the brain.

Mao M, Zhou Y, Zhang H, Deng P, Yang J, Zhong J, Li N, Liu Q, Li X, Wu X, Cheng Y. Mao M, et al. Among authors: li x, li n. Eur J Med Chem. 2025 Jun 5;290:117587. doi: 10.1016/j.ejmech.2025.117587. Epub 2025 Mar 29. Eur J Med Chem. 2025. PMID: 40168910

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