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Page 1
Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
Jain A, Heremans I, Rademaker G, Detomasi TC, Hernandez GA, Zhang J, Gupta S, von Linde T, Lange M, Spacci M, Rohweder P, Anderson D, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R. Jain A, et al. Among authors: rademaker g. bioRxiv [Preprint]. 2024 Dec 14:2024.12.13.628212. doi: 10.1101/2024.12.13.628212. bioRxiv. 2024. Update in: Science. 2025 Mar 28;387(6741):eadq8331. doi: 10.1126/science.adq8331. PMID: 39713462 Free PMC article. Updated. Preprint.
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer.
Rademaker G, Hernandez GA, Seo Y, Dahal S, Miller-Phillips L, Li AL, Peng XL, Luan C, Qiu L, Liegeois MA, Wang B, Wen KW, Kim GE, Collisson EA, Kruger SF, Boeck S, Ormanns S, Guenther M, Heinemann V, Haas M, Looney MR, Yeh JJ, Zoncu R, Perera RM. Rademaker G, et al. Nature. 2025 May 21. doi: 10.1038/s41586-025-09017-8. Online ahead of print. Nature. 2025. PMID: 40399683
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.
Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D. Kovalski JR, et al. Among authors: rademaker g. Nat Cell Biol. 2025 Mar;27(3):518-529. doi: 10.1038/s41556-024-01604-7. Epub 2025 Feb 4. Nat Cell Biol. 2025. PMID: 39905246
Correction: Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer.
Nokin MJ, Bellier J, Durieux F, Peulen O, Rademaker G, Gabriel M, Monseur C, Charloteaux B, Verbeke L, van Laere S, Roncarati P, Herfs M, Lambert C, Scheijen J, Schalkwijk C, Colige A, Caers J, Delvenne P, Turtoi A, Castronovo V, Bellahcène A. Nokin MJ, et al. Among authors: rademaker g. Breast Cancer Res. 2025 Jun 4;27(1):99. doi: 10.1186/s13058-025-02044-3. Breast Cancer Res. 2025. PMID: 40468322 Free PMC article. No abstract available.
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
Jain A, Heremans I, Rademaker G, Detomasi TC, Rohweder P, Anderson D, Zhang J, Hernandez GA, Gupta S, von Linde T, Lange M, Spacci M, Luo J, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R. Jain A, et al. Among authors: rademaker g. Science. 2025 Mar 28;387(6741):eadq8331. doi: 10.1126/science.adq8331. Epub 2025 Mar 28. Science. 2025. PMID: 40146846
Functional screen for mediators of onco-mRNA translation specificity.
Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D. Kovalski JR, et al. Among authors: rademaker g. bioRxiv [Preprint]. 2024 Oct 11:2024.10.10.617637. doi: 10.1101/2024.10.10.617637. bioRxiv. 2024. Update in: Nat Cell Biol. 2025 Mar;27(3):518-529. doi: 10.1038/s41556-024-01604-7. PMID: 39416102 Free PMC article. Updated. Preprint.
46 results