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420 results

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Page 1
CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.
Fleming TJ, Antoszewski M, Lambo S, Gundry MC, Piussi R, Wahlster L, Shah S, Reed FE, Dong KD, Paulo JA, Gygi SP, Mimoso C, Goldman SR, Adelman K, Perry JA, Pikman Y, Stegmaier K, Barrachina MN, Machlus KR, Hovestadt V, Arruda A, Minden MD, Voit RA, Sankaran VG. Fleming TJ, et al. Among authors: arruda a. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630680. doi: 10.1101/2024.12.30.630680. bioRxiv. 2024. PMID: 39803492 Free PMC article. Preprint.
Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML.
Zeng AGX, Iacobucci I, Shah S, Mitchell A, Wong G, Bansal S, Chen D, Gao Q, Kim H, Kennedy JA, Arruda A, Minden MD, Haferlach T, Mullighan CG, Dick JE. Zeng AGX, et al. Among authors: arruda a. bioRxiv [Preprint]. 2024 Nov 1:2023.12.26.573390. doi: 10.1101/2023.12.26.573390. bioRxiv. 2024. Update in: Blood Cancer Discov. 2025 Jul 1;6(4):307-324. doi: 10.1158/2643-3230.BCD-24-0342. PMID: 38234771 Free PMC article. Updated. Preprint.
FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells.
Araújo JL, Wagenblast E, Voisin V, McLeod J, Gan OI, Bansal S, Jin L, Mitchell A, Gratton B, Cutting S, Arruda A, Doedens M, Travas A, Kim D, Capo-Chichi JM, Abelson S, Minden MD, Wang JCY, Sobrinho-Simões MA, Pinto-do-Ó P, Lechman E, Dick JE. Araújo JL, et al. Among authors: arruda a. Blood. 2025 May 15;145(20):2361-2373. doi: 10.1182/blood.2024025886. Blood. 2025. PMID: 39841016 Free article.
Blood-based proteomic profiling identifies OSMR as a novel biomarker of AML outcomes.
Reville PK, Wang B, Marvin-Peek J, Yuan B, Kuo YA, Garza A, Root J, Qiao W, Arruda A, Veletic I, Liu Y, Short NJ, DiNardo CD, Kadia TM, Daver NG, Lorenzi PL, Sasaki K, Kornblau S, Minden MD, Ravandi F, Kantarjian HM, Abbas HA. Reville PK, et al. Among authors: arruda a. Blood. 2025 Jun 19;145(25):3015-3029. doi: 10.1182/blood.2024027244. Blood. 2025. PMID: 40179376 Free article.
Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation.
Zeng AGX, Iacobucci I, Shah S, Mitchell A, Wong G, Bansal S, Chen D, Gao Q, Kim H, Kennedy JA, Arruda A, Minden MD, Haferlach T, Mullighan CG, Dick JE. Zeng AGX, et al. Among authors: arruda a. Blood Cancer Discov. 2025 Jul 1;6(4):307-324. doi: 10.1158/2643-3230.BCD-24-0342. Blood Cancer Discov. 2025. PMID: 40294241 Free PMC article.
A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome.
Boutzen H, Madani Tonekaboni SA, Chan-Seng-Yue M, Murison A, Takayama N, Mbong N, Wagenblast E, Orouji E, Arruda A, Mitchell A, Notta F, Minden MD, Lupien M, Kaufmann KB, Dick JE. Boutzen H, et al. Among authors: arruda a. Leukemia. 2022 Nov;36(11):2690-2704. doi: 10.1038/s41375-022-01697-9. Epub 2022 Sep 21. Leukemia. 2022. PMID: 36131042 Free PMC article.
420 results