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Page 1
CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.
Fleming TJ, Antoszewski M, Lambo S, Gundry MC, Piussi R, Wahlster L, Shah S, Reed FE, Dong KD, Paulo JA, Gygi SP, Mimoso C, Goldman SR, Adelman K, Perry JA, Pikman Y, Stegmaier K, Barrachina MN, Machlus KR, Hovestadt V, Arruda A, Minden MD, Voit RA, Sankaran VG. Fleming TJ, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630680. doi: 10.1101/2024.12.30.630680. bioRxiv. 2024. PMID: 39803492 Free PMC article. Preprint.
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
Chou CC, Vest R, Prado MA, Wilson-Grady J, Paulo JA, Shibuya Y, Moran-Losada P, Lee TT, Luo J, Gygi SP, Kelly JW, Finley D, Wernig M, Wyss-Coray T, Frydman J. Chou CC, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2025 Jan 13:2023.03.27.534444. doi: 10.1101/2023.03.27.534444. bioRxiv. 2025. Update in: Nat Cell Biol. 2025 Apr;27(4):619-632. doi: 10.1038/s41556-025-01623-y. PMID: 37034684 Free PMC article. Updated. Preprint.
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.
Mitchell W, Goeminne LJE, Tyshkovskiy A, Zhang S, Chen JY, Paulo JA, Pierce KA, Choy AH, Clish CB, Gygi SP, Gladyshev VN. Mitchell W, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Nov 27:2023.06.30.546730. doi: 10.1101/2023.06.30.546730. bioRxiv. 2023. Update in: Elife. 2024 Mar 22;12:RP90579. doi: 10.7554/eLife.90579. PMID: 37425825 Free PMC article. Updated. Preprint.
The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway.
Chen H, Ferguson CJ, Mitchell DC, Titus A, Paulo JA, Hwang A, Lin TH, Yano H, Gu W, Song SK, Yuede CM, Gygi SP, Bonni A, Kim AH. Chen H, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Jun 29:2023.10.24.563880. doi: 10.1101/2023.10.24.563880. bioRxiv. 2024. Update in: Cell Rep. 2025 Feb 25;44(2):115231. doi: 10.1016/j.celrep.2025.115231. PMID: 37961719 Free PMC article. Updated. Preprint.
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST.
Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Gygi SP, Schulman BA, Wilfling F, Coon JJ, Harper JW. Kraus F, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Oct 20:2024.03.26.586828. doi: 10.1101/2024.03.26.586828. bioRxiv. 2024. Update in: Sci Adv. 2025 Jan 24;11(4):eadu5787. doi: 10.1126/sciadv.adu5787. PMID: 38585873 Free PMC article. Updated. Preprint.
750 results