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139 results

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Page 1
Simulating 500 million years of evolution with a language model.
Hayes T, Rao R, Akin H, Sofroniew NJ, Oktay D, Lin Z, Verkuil R, Tran VQ, Deaton J, Wiggert M, Badkundri R, Shafkat I, Gong J, Derry A, Molina RS, Thomas N, Khan YA, Mishra C, Kim C, Bartie LJ, Nemeth M, Hsu PD, Sercu T, Candido S, Rives A. Hayes T, et al. Among authors: khan ya. Science. 2025 Feb 21;387(6736):850-858. doi: 10.1126/science.ads0018. Epub 2025 Jan 16. Science. 2025. PMID: 39818825
SNARE disassembly requires Sec18/NSF side loading.
Khan YA, White KI, Pfuetzner RA, Singal B, Esquivies L, Mckenzie G, Liu F, DeLong K, Choi UB, Montabana E, Mclaughlin T, Wickner WT, Brunger AT. Khan YA, et al. Nat Struct Mol Biol. 2025 Jul 2. doi: 10.1038/s41594-025-01590-w. Online ahead of print. Nat Struct Mol Biol. 2025. PMID: 40604310
Addendum: Accurate structure prediction of biomolecular interactions with AlphaFold 3.
Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, Ronneberger O, Willmore L, Ballard AJ, Bambrick J, Bodenstein SW, Evans DA, Hung CC, O'Neill M, Reiman D, Tunyasuvunakool K, Wu Z, Žemgulytė A, Arvaniti E, Beattie C, Bertolli O, Bridgland A, Cherepanov A, Congreve M, Cowen-Rivers AI, Cowie A, Figurnov M, Fuchs FB, Gladman H, Jain R, Khan YA, Low CMR, Perlin K, Potapenko A, Savy P, Singh S, Stecula A, Thillaisundaram A, Tong C, Yakneen S, Zhong ED, Zielinski M, Žídek A, Bapst V, Kohli P, Jaderberg M, Hassabis D, Jumper JM. Abramson J, et al. Among authors: khan ya. Nature. 2024 Dec;636(8042):E4. doi: 10.1038/s41586-024-08416-7. Nature. 2024. PMID: 39604737 Free PMC article. No abstract available.
Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active proteoform that supports myocardial function.
Loughran G, De Pace R, Ding N, Zhang J, Jungreis I, Carancini G, Mudge JM, Wang J, Kellis M, Atkins JF, Baranov PV, Firth AE, Li X, Bonifacino JS, Khan YA. Loughran G, et al. Among authors: khan ya. bioRxiv [Preprint]. 2025 Jan 14:2024.08.30.610563. doi: 10.1101/2024.08.30.610563. bioRxiv. 2025. PMID: 39372779 Free PMC article. Preprint.
Accurate structure prediction of biomolecular interactions with AlphaFold 3.
Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, Ronneberger O, Willmore L, Ballard AJ, Bambrick J, Bodenstein SW, Evans DA, Hung CC, O'Neill M, Reiman D, Tunyasuvunakool K, Wu Z, Žemgulytė A, Arvaniti E, Beattie C, Bertolli O, Bridgland A, Cherepanov A, Congreve M, Cowen-Rivers AI, Cowie A, Figurnov M, Fuchs FB, Gladman H, Jain R, Khan YA, Low CMR, Perlin K, Potapenko A, Savy P, Singh S, Stecula A, Thillaisundaram A, Tong C, Yakneen S, Zhong ED, Zielinski M, Žídek A, Bapst V, Kohli P, Jaderberg M, Hassabis D, Jumper JM. Abramson J, et al. Among authors: khan ya. Nature. 2024 Jun;630(8016):493-500. doi: 10.1038/s41586-024-07487-w. Epub 2024 May 8. Nature. 2024. PMID: 38718835 Free PMC article.
139 results