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Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong JY, Tan YK, Thumboo J, van Loosdregt J, Albani S. Rossetti M, et al. Among authors: van loosdregt j. J Immunol. 2015 Jan 1;194(1):113-24. doi: 10.4049/jimmunol.1401145. Epub 2014 Dec 1. J Immunol. 2015. PMID: 25452562 Free PMC article.
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.
van Loosdregt J, Vercoulen Y, Guichelaar T, Gent YY, Beekman JM, van Beekum O, Brenkman AB, Hijnen DJ, Mutis T, Kalkhoven E, Prakken BJ, Coffer PJ. van Loosdregt J, et al. Among authors: van beekum o. Blood. 2010 Feb 4;115(5):965-74. doi: 10.1182/blood-2009-02-207118. Epub 2009 Dec 7. Blood. 2010. PMID: 19996091 Free article.
Canonical Wnt signaling negatively modulates regulatory T cell function.
van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ. van Loosdregt J, et al. Among authors: van boxtel r, van es jh. Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15. Immunity. 2013. PMID: 23954131 Free article.
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.
Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, van de Graaf SF, van Loosdregt J, van Beekum O, Hamers N, van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, Kalkhoven E. Gao Y, et al. Among authors: van loosdregt j, van de graaf sf, van leenen d, van beekum o. Nat Commun. 2013;4:2656. doi: 10.1038/ncomms3656. Nat Commun. 2013. PMID: 24141283 Free article.
52 results