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Copper(II)-Catalyzed Enantioselective Friedel-Crafts Alkylation Reactions of 1-Naphthols and Electron-Rich Phenols with Trifluoropyruvates.
Xue L, Yang J, He L, Hou X, Kan M, Li J, Yu T, Yao C, Li YM. Xue L, et al. J Org Chem. 2025 Jul 3. doi: 10.1021/acs.joc.5c00112. Online ahead of print. J Org Chem. 2025. PMID: 40607999
The reactions were carried out on a gram scale with low catalyst loading. Especially, the optically pure GABA(B) positive allosteric modulator (R)-BHFF was prepared using this protocol....
The reactions were carried out on a gram scale with low catalyst loading. Especially, the optically pure GABA(B) positive allosteric …
Evaluating Selective Apical Electrode Deactivation for Improving Cochlear Implant Outcomes.
Berg KA, Noble JH, Dawant BM, Gifford RH. Berg KA, et al. Trends Hear. 2025 Jan-Dec;29:23312165251353638. doi: 10.1177/23312165251353638. Epub 2025 Jul 3. Trends Hear. 2025. PMID: 40607992
Twenty-one adults (30 ears) with cochlear implants completed an A-B-A-B study to compare the participant's clinical map with all electrodes active (A) and their clinical map with the second most apical electrode deactivated (B). ...This study also investigate …
Twenty-one adults (30 ears) with cochlear implants completed an A-B-A-B study to compare the participant's clinical map with a …
Changes in natriuretic peptide levels following patiromer-enabled optimization of medical therapy in heart failure: A post hoc analysis of the DIAMOND study.
Kalogeropoulos AP, Hameed I, Anker SD, Bayes-Genis A, Böhm M, Budden J, Cleland JGF, Coats AJS, Ezekowitz JA, Filippatos G, Goudev A, Khan MS, Lindenfeld J, Lund LH, Merkely B, Mentz RJ, Metra M, Moutchia J, Perrin A, Ponikowski P, Priest EL, Rossignol P, Senni M, Shaver C, Waechter S, Weir MR, Pitt B, Butler J. Kalogeropoulos AP, et al. Eur J Heart Fail. 2025 Jul 3. doi: 10.1002/ejhf.3754. Online ahead of print. Eur J Heart Fail. 2025. PMID: 40607983
In this post-hoc analysis, we evaluated the effect of patiromer-enabled RAASi optimization on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, an established surrogate endpoint for clinical outcomes in HFrEF. ...
In this post-hoc analysis, we evaluated the effect of patiromer-enabled RAASi optimization on N-terminal pro-B-type natriuretic pepti …
A Double-Blind, Placebo-Controlled, Single-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT-101, an RNAi Therapeutic Targeting HBV Infection.
Zhang J, Li J, Wu L, Song Y, Li X, Gao Q, Wu J, Wang D, Zhang Z, Zhang S, Ding L, Ma Y, Ma H, Jia J, Dong R. Zhang J, et al. Clin Pharmacol Drug Dev. 2025 Jul 3. doi: 10.1002/cpdd.1569. Online ahead of print. Clin Pharmacol Drug Dev. 2025. PMID: 40607962
HT-101, a liver-targeted N-acetylgalactosamine-conjugated ribonucleic acid interference therapeutic, exhibits promising potential for the treatment of chronic hepatitis B virus infection. This randomized, double-blind, placebo-controlled, and single-ascending-dose Phase Ia …
HT-101, a liver-targeted N-acetylgalactosamine-conjugated ribonucleic acid interference therapeutic, exhibits promising potential for the tr …
Single-cell transcriptomic analysis reveals therapeutic mechanisms of adipose-derived stem cell exosomes in sepsis-induced lung injury.
Wu SC, Rau CS, Wu YC, Lin CW, Lu TH, Tsai CW, Yang MY, Hsieh CH. Wu SC, et al. Int J Surg. 2025 Jul 2. doi: 10.1097/JS9.0000000000002894. Online ahead of print. Int J Surg. 2025. PMID: 40607951
Treatment altered lung cellular composition, increasing neutrophils, NKT cells, and monocytes while decreasing B and T cells. Gene expression analysis revealed downregulation of pro-inflammatory markers (TNF, IL-10, CCL3, CCL4) and upregulation of tissue repair pathways. . …
Treatment altered lung cellular composition, increasing neutrophils, NKT cells, and monocytes while decreasing B and T cells. Gene ex …
SARS-CoV-2-Induced PAPOLG Contributes to Inflammation Response by Stabilizing NF-κB mRNA.
Liao Y, Chen Q, Wang H, Pan P, Zhou L, Jiang J, Lan Q, Xu X, Lin X, Peng Y, Yang Y, An S, Ye L, Liang H. Liao Y, et al. J Med Virol. 2025 Jul;97(7):e70478. doi: 10.1002/jmv.70478. J Med Virol. 2025. PMID: 40607946
The levels of PAPOLG, transcriptional regulator nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), and cytokines TNF-alpha and IL-6 were measured, along with an assessment of NF-kappaB mRNA stability. ...
The levels of PAPOLG, transcriptional regulator nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), and cytok …
Preoperative von Willebrand factor is an independent predictive biomarker for posthepatectomy liver failure - a multivariable model with APRI+ALBI.
Dong Y, Gregory LA, Podrascanin V, Santol J, Ammann M, Pereyra D, Hackl H, Li Z, Truty MJ, Warner SG, Smoot RL, Gruenberger T, Nagorney DM, Starlinger PP. Dong Y, et al. Liver Transpl. 2025 Jul 4. doi: 10.1097/LVT.0000000000000676. Online ahead of print. Liver Transpl. 2025. PMID: 40607909
Predictive probability for PHLF was assessed using ROC analysis and validated in an external Austrian cohort of 283 patients (2008-2017). vWF-Ag was then integrated into the existing APRI+ALBI multivariable model. RESULTS: PHLF grade B/C was reported in 56 patients (10.5%) …
Predictive probability for PHLF was assessed using ROC analysis and validated in an external Austrian cohort of 283 patients (2008-2017). vW …
Melodic Contour Identification by Cochlear-Implant Listeners With Asymmetric Phantom Pulses Presented to Apical Electrodes.
Macherey O, Carlyon RP. Macherey O, et al. Ear Hear. 2025 Jul 3. doi: 10.1097/AUD.0000000000001691. Online ahead of print. Ear Hear. 2025. PMID: 40607862
OBJECTIVES: (a) To compare performance by cochlear-implant listeners on a melodic contour identification task when the fundamental frequency (F0) is encoded explicitly by single-pulse-per-period (SPP) pulse trains presented to an apical channel, by amplitude modulation of high-ra …
OBJECTIVES: (a) To compare performance by cochlear-implant listeners on a melodic contour identification task when the fundamental frequency …
Endothelin-1 and Accelerated Cardiac Allograft Vasculopathy After Heart Transplantation.
Parikh RV, Klomhaus A, Kim JS, Assi A, Tehrani D, Campbell D, Bang L, Fleming R, Saito K, Nishi T, Honda Y, Khush KK, Fearon WF, Nsair A, Fonarow GC. Parikh RV, et al. Circ Heart Fail. 2025 Jul 2:e013288. doi: 10.1161/CIRCHEARTFAILURE.125.013288. Online ahead of print. Circ Heart Fail. 2025. PMID: 40607852 No abstract available.
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