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High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.
Luteijn MJ, Bhaskar V, Trojer D, Schürz M, Mahboubi H, Handl C, Pizzato N, Pfeifer M, Dafinca R, Voshol H, Giorgetti E, Manneville C, Garnier IPM, Müller M, Zeng F, Buntin K, Markwalder R, Schröder H, Weiler J, Khar D, Schuhmann T, Groot-Kormelink PJ, Keller CG, Farmer P, MacKay A, Beibel M, Roma G, D'Ario G, Merkl C, Schebesta M, Hild M, Elwood F, Vahsen BF, Ripin N, Clery A, Allain F, Labow M, Gabriel D, Chao JA, Talbot K, Nash M, Hunziker J, Meisner-Kober NC. Luteijn MJ, et al. Nucleic Acids Res. 2025 Apr 10;53(7):gkaf253. doi: 10.1093/nar/gkaf253. Nucleic Acids Res. 2025. PMID: 40207633 Free PMC article.
A Simple and Efficient CRISPR Technique for Protein Tagging.
Zeng F, Beck V, Schuierer S, Garnier I, Manneville C, Agarinis C, Morelli L, Quinn L, Knehr J, Roma G, Bassilana F, Nash M. Zeng F, et al. Cells. 2020 Dec 5;9(12):2618. doi: 10.3390/cells9122618. Cells. 2020. PMID: 33291479 Free PMC article.
STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.
Morozzi G, Rothen J, Toussaint G, De Lange K, Westritschnig K, Doelemeyer A, Ueberschlag VP, Kahle P, Lambert C, Obrecht M, Beckmann N, Ritter V, Panesar M, Stauffer D, Garnier I, Mueller M, Guerini D, Keller CG, Knehr J, Roma G, Bidinosti M, Brachat S, Morvan F, Fornaro M. Morozzi G, et al. iScience. 2021 Nov 14;24(12):103434. doi: 10.1016/j.isci.2021.103434. eCollection 2021 Dec 17. iScience. 2021. PMID: 34877494 Free PMC article.