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The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA.
Hardikar S, Ren R, Ying Z, Horton JR, Bramble MD, Liu B, Lu Y, Liu B, Dan J, Zhang X, Cheng X, Chen T. Hardikar S, et al. Among authors: chen t. bioRxiv [Preprint]. 2023 Dec 15:2023.12.15.571946. doi: 10.1101/2023.12.15.571946. bioRxiv. 2023. Update in: Sci Adv. 2024 Aug 23;10(34):eadr0036. doi: 10.1126/sciadv.adr0036. PMID: 38168392 Free PMC article. Updated. Preprint.
Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration.
Lyu Y, Kim SJ, Humphrey ES, Nayak R, Guan Y, Liang Q, Kim KH, Tan Y, Dou J, Sun H, Song X, Nagarajan P, Gerner-Mauro KN, Jin K, Liu V, Hassan RH, Johnson ML, Deliu LP, You Y, Sharma A, Pasolli HA, Lu Y, Zhang J, Mohanty V, Chen K, Yang YJ, Chen T, Ge Y. Lyu Y, et al. Among authors: chen k, chen t. Cell. 2024 Dec 26;187(26):7414-7432.e26. doi: 10.1016/j.cell.2024.10.007. Epub 2024 Oct 29. Cell. 2024. PMID: 39476839
MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors.
Chen S, Hou J, Jaffery R, Guerrero A, Fu R, Shi L, Zheng N, Bohat R, Egan NA, Yu C, Sharif S, Lu Y, He W, Wang S, Gjuka D, Stone EM, Shah PA, Rodon Ahnert J, Chen T, Liu X, Bedford MT, Xu H, Peng W. Chen S, et al. Among authors: chen t. J Immunother Cancer. 2024 Sep 23;12(9):e009600. doi: 10.1136/jitc-2024-009600. J Immunother Cancer. 2024. PMID: 39313308 Free PMC article.
GSK-3484862 targets DNMT1 for degradation in cells.
Chen Q, Liu B, Zeng Y, Hwang JW, Dai N, Corrêa IR Jr, Estecio MR, Zhang X, Santos MA, Chen T, Cheng X. Chen Q, et al. Among authors: chen t. NAR Cancer. 2023 May 17;5(2):zcad022. doi: 10.1093/narcan/zcad022. eCollection 2023 Jun. NAR Cancer. 2023. PMID: 37206360 Free PMC article.
Quinoline-based compounds can inhibit diverse enzymes that act on DNA.
Zhou J, Chen Q, Ren R, Yang J, Liu B, Horton JR, Chang C, Li C, Maksoud L, Yang Y, Rotili D, Jain AK, Zhang X, Blumenthal RM, Chen T, Gao Y, Valente S, Mai A, Cheng X. Zhou J, et al. Among authors: chen q, chen t. Cell Chem Biol. 2024 Dec 19;31(12):2112-2127.e6. doi: 10.1016/j.chembiol.2024.09.007. Epub 2024 Oct 21. Cell Chem Biol. 2024. PMID: 39437789 Free article.
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