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Proteomic-based stemness score measures oncogenic dedifferentiation and enables the identification of druggable targets.
Kołodziejczak-Guglas I, Simões RLS, de Souza Santos E, Demicco EG, Lazcano Segura RN, Ma W, Wang P, Geffen Y, Storrs E, Petralia F, Colaprico A, da Veiga Leprevost F, Pugliese P, Ceccarelli M, Noushmehr H, Nesvizhskii AI, Kamińska B, Priebe W, Lubiński J, Zhang B, Lazar AJ, Kurzawa P, Mesri M, Robles AI; Clinical Proteomic Tumor Analysis Consortium; Ding L, Malta TM, Wiznerowicz M. Kołodziejczak-Guglas I, et al. Cell Genom. 2025 Jun 11;5(6):100851. doi: 10.1016/j.xgen.2025.100851. Epub 2025 Apr 17. Cell Genom. 2025. PMID: 40250426 Free article.
Precision proteogenomics reveals pan-cancer impact of germline variants.
Martins Rodrigues F, Terekhanova NV, Imbach KJ, Clauser KR, Esai Selvan M, Mendizabal I, Geffen Y, Akiyama Y, Maynard M, Yaron TM, Li Y, Cao S, Storrs EP, Gonda OS, Gaite-Reguero A, Govindan A, Kawaler EA, Wyczalkowski MA, Klein RJ, Turhan B, Krug K, Mani DR, Leprevost FDV, Nesvizhskii AI, Carr SA, Fenyö D, Gillette MA, Colaprico A, Iavarone A, Robles AI, Huang KL, Kumar-Sinha C, Aguet F, Lazar AJ, Cantley LC, Marigorta UM, Gümüş ZH, Bailey MH, Getz G, Porta-Pardo E, Ding L; Clinical Proteomic Tumor Analysis Consortium. Martins Rodrigues F, et al. Among authors: gumus zh. Cell. 2025 May 1;188(9):2312-2335.e26. doi: 10.1016/j.cell.2025.03.026. Epub 2025 Apr 14. Cell. 2025. PMID: 40233739 Free article.
Clonal Hematopoiesis of Indeterminate Potential in Crohn's Disease and Ulcerative Colitis.
Esai Selvan M, Nathan DI, Guisado D, Collatuzzo G, Iruvanti S, Boffetta P, Mascarenhas J, Hoffman R, Cohen LJ, Marcellino BK, Gümüş ZH. Esai Selvan M, et al. Among authors: gumus zh. medRxiv [Preprint]. 2024 Aug 7:2024.08.06.24311497. doi: 10.1101/2024.08.06.24311497. medRxiv. 2024. Update in: Inflamm Bowel Dis. 2025 Jan 06:izae312. doi: 10.1093/ibd/izae312. PMID: 39148820 Free PMC article. Updated. Preprint.
A unique serum IgG glycosylation signature predicts development of Crohn's disease and is associated with pathogenic antibodies to mannose glycan.
Gaifem J, Rodrigues CS, Petralia F, Alves I, Leite-Gomes E, Cavadas B, Dias AM, Moreira-Barbosa C, Revés J, Laird RM, Novokmet M, Štambuk J, Habazin S, Turhan B, Gümüş ZH, Ungaro R, Torres J, Lauc G, Colombel JF, Porter CK, Pinho SS. Gaifem J, et al. Among authors: gumus zh. Nat Immunol. 2024 Sep;25(9):1692-1703. doi: 10.1038/s41590-024-01916-8. Epub 2024 Jul 30. Nat Immunol. 2024. PMID: 39080486 Free PMC article.
PhosNetVis: A web-based tool for fast kinase-substrate enrichment analysis and interactive 2D/3D network visualizations of phosphoproteomics data.
Rawal O, Turhan B, Peradejordi IF, Chandrasekar S, Kalayci S, Gnjatic S, Johnson J, Bouhaddou M, Gümüş ZH. Rawal O, et al. Among authors: gumus zh. ArXiv [Preprint]. 2024 Dec 18:arXiv:2402.05016v4. ArXiv. 2024. Update in: Patterns (N Y). 2025 Jan 10;6(1):101148. doi: 10.1016/j.patter.2024.101148. PMID: 39010877 Free PMC article. Updated. Preprint.
An immunogenetic basis for lung cancer risk.
Krishna C, Tervi A, Saffern M, Wilson EA, Yoo SK, Mars N, Roudko V, Cho BA, Jones SE, Vaninov N, Selvan ME, Gümüş ZH; FinnGen§; Lenz TL, Merad M, Boffetta P, Martínez-Jiménez F, Ollila HM, Samstein RM, Chowell D. Krishna C, et al. Among authors: gumus zh. Science. 2024 Feb 23;383(6685):eadi3808. doi: 10.1126/science.adi3808. Epub 2024 Feb 23. Science. 2024. PMID: 38386728 Free PMC article.
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation.
Lin YC, Swendeman S, Moreira IS, Ghosh A, Kuo A, Rosário-Ferreira N, Guo S, Culbertson A, Levesque MV, Cartier A, Seno T, Schmaier A, Galvani S, Inoue A, Parikh SM, FitzGerald GA, Zurakowski D, Liao M, Flaumenhaft R, Gümüş ZH, Hla T. Lin YC, et al. Among authors: gumus zh. Sci Signal. 2024 Feb 20;17(824):eadg9256. doi: 10.1126/scisignal.adg9256. Epub 2024 Feb 20. Sci Signal. 2024. PMID: 38377179 Free PMC article.
71 results