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A phase I / IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis.
Vachhani P, Tan P, Watson AM, Wu SJ, Baker R, Cheung S, Lee SE, Chen CC, Chen TY, Hsiao HH, Lee JH, Masarova L, Tan SY, Baskar J, Charlton B, Findlay A, Hamprecht D, Jarolimek W, Leadbetter J, Miller J, Morgan K, Zahoor A, Hobbs G. Vachhani P, et al. Among authors: findlay a. Haematologica. 2025 Apr 17. doi: 10.3324/haematol.2024.287231. Online ahead of print. Haematologica. 2025. PMID: 40241543 Free article.
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.
Chitty JL, Yam M, Perryman L, Parker AL, Skhinas JN, Setargew YFI, Mok ETY, Tran E, Grant RD, Latham SL, Pereira BA, Ritchie SC, Murphy KJ, Trpceski M, Findlay AD, Melenec P, Filipe EC, Nadalini A, Velayuthar S, Major G, Wyllie K, Papanicolaou M, Ratnaseelan S, Phillips PA, Sharbeen G, Youkhana J, Russo A, Blackwell A, Hastings JF, Lucas MC, Chambers CR, Reed DA, Stoehr J, Vennin C, Pidsley R, Zaratzian A, Da Silva AM, Tayao M, Charlton B, Herrmann D, Nobis M, Clark SJ, Biankin AV, Johns AL, Croucher DR, Nagrial A, Gill AJ, Grimmond SM; Australian Pancreatic Cancer Genome Initiative (APGI); Australian Pancreatic Cancer Matrix Atlas (APMA); Pajic M, Timpson P, Jarolimek W, Cox TR. Chitty JL, et al. Among authors: findlay ad. Nat Cancer. 2023 Sep;4(9):1326-1344. doi: 10.1038/s43018-023-00614-y. Epub 2023 Aug 28. Nat Cancer. 2023. PMID: 37640930 Free PMC article.
Author Correction: Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis.
Chaudhari N, Findlay AD, Stevenson AW, Clemons TD, Yao Y, Joshi A, Sayyar S, Wallace G, Rea S, Toshniwal P, Deng Z, Melton PE, Hortin N, Iyer KS, Jarolimek W, Wood FM, Fear MW. Chaudhari N, et al. Among authors: findlay ad. Nat Commun. 2023 Jan 10;14(1):135. doi: 10.1038/s41467-023-35849-x. Nat Commun. 2023. PMID: 36627321 Free PMC article. No abstract available.
Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.
Bengoechea R, Findlay AR, Bhadra AK, Shao H, Stein KC, Pittman SK, Daw JA, Gestwicki JE, True HL, Weihl CC. Bengoechea R, et al. Among authors: findlay ar. J Clin Invest. 2025 May 15;135(10):e194757. doi: 10.1172/JCI194757. eCollection 2025 May 15. J Clin Invest. 2025. PMID: 40371652 Free PMC article. No abstract available.
203 results