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Evidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill.
Munroe ES, Spicer A, Castellvi-Font A, Zalucky A, Dianti J, Graham Linck E, Talisa V, Urner M, Angus DC, Baedorf-Kassis E, Blette B, Bos LD, Buell KG, Casey JD, Calfee CS, Del Sorbo L, Estenssoro E, Ferguson ND, Giblon R, Granholm A, Harhay MO, Heath A, Hodgson C, Houle T, Jiang C, Kramer L, Lawler PR, Leligdowicz A, Li F, Liu K, Maiga A, Maslove D, McArthur C, McAuley DF, Serpa Neto A, Oosthuysen C, Perner A, Prescott HC, Rochwerg B, Sahetya S, Samoilenko M, Schnitzer ME, Seitz KP, Shah F, Shankar-Hari M, Sinha P, Slutsky AS, Qian ET, Webb SA, Young PJ, Zampieri FG, Zarychanski R, Fan E, Semler MW, Churpek M, Goligher EC; Platform of Randomized Adaptive Clinical Trials in Critical Illness (PRACTICAL) investigators; Evidence-based Individualized Treatment Effects (EvITE) Group. Munroe ES, et al. Among authors: graham linck e. Lancet Respir Med. 2025 Jun;13(6):556-568. doi: 10.1016/S2213-2600(25)00054-2. Epub 2025 Apr 15. Lancet Respir Med. 2025. PMID: 40250459 Review.
Machine Learning-Driven Analysis of Individualized Treatment Effects Comparing Buprenorphine and Naltrexone in Opioid Use Disorder Relapse Prevention.
Afshar M, Graham Linck EJ, Spicer AB, Rotrosen J, Salisbury-Afshar EM, Sinha P, Semler MW, Churpek MM. Afshar M, et al. Among authors: graham linck ej. J Addict Med. 2024 Sep-Oct 01;18(5):511-519. doi: 10.1097/ADM.0000000000001313. Epub 2024 May 22. J Addict Med. 2024. PMID: 38776423 Free PMC article. Clinical Trial.
Individualized Treatment Effects of Bougie versus Stylet for Tracheal Intubation in Critical Illness.
Seitz KP, Spicer AB, Casey JD, Buell KG, Qian ET, Graham Linck EJ, Driver BE, Self WH, Ginde AA, Trent SA, Gandotra S, Smith LM, Page DB, Vonderhaar DJ, West JR, Joffe AM, Doerschug KC, Hughes CG, Whitson MR, Prekker ME, Rice TW, Sinha P, Semler MW, Churpek MM. Seitz KP, et al. Among authors: graham linck ej. Am J Respir Crit Care Med. 2023 Jun 15;207(12):1602-1611. doi: 10.1164/rccm.202209-1799OC. Am J Respir Crit Care Med. 2023. PMID: 36877594 Free PMC article.