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Limited association between HRR gene alterations and HRD in molecular tumor board cancer samples: Who should be tested for HRD?
Schubart C, Tögel L, Carta MG, Hetzner P, Helbig L, Zaglas C, Ziegler M, Stöhr R, Hölsken A, Hoyer J, Ferrazzi F, Neufert C, Lettmaier S, Pavel M, Golcher H, Mueller SK, Fuchs F, Schulmeyer CE, Beckmann MW, Wullich B, Agaimy A, Reis A, Hartmann A, Meidenbauer N, Spoerl S, Haller F, Moskalev EA. Schubart C, et al. Among authors: neufert c. Int J Cancer. 2025 Apr 25. doi: 10.1002/ijc.35457. Online ahead of print. Int J Cancer. 2025. PMID: 40278800
The outcome of patients with inflammatory bowel disease-associated colorectal cancer is not worse than that of patients with sporadic colorectal cancer-a matched-pair analysis of survival.
Vitali F, Wein A, Rath T, Eckstein M, Neufert C, Siebler J, Atreya R, Hartmann A, Hohenberger W, Weber K, Neurath MF, Grützmann R, Merkel S. Vitali F, et al. Among authors: neufert c. Int J Colorectal Dis. 2022 Feb;37(2):381-391. doi: 10.1007/s00384-021-04072-9. Epub 2021 Dec 4. Int J Colorectal Dis. 2022. PMID: 34865179 Free PMC article.
[Case report: persistent fever after SARS-CoV-2 infection].
Kliem T, Strobel D, Heinke F, Pavel M, Neurath MF, Neufert C. Kliem T, et al. Among authors: neufert c. Inn Med (Heidelb). 2022 Jun;63(6):662-665. doi: 10.1007/s00108-022-01315-x. Epub 2022 Mar 17. Inn Med (Heidelb). 2022. PMID: 35301546 Free PMC article. German.
CD71 expressing circulating neutrophils serve as a novel prognostic biomarker for metastatic spread and reduced outcome in pancreatic ductal adenocarcinoma patients.
Hansen FJ, Mittelstädt A, Clausen FN, Knoedler S, Knoedler L, Klöckner S, Kuchenreuther I, Mazurie J, Arnold LS, Anthuber A, Jacobsen A, Merkel S, Weisel N, Klösch B, Karabiber A, Tacyildiz I, Czubayko F, Reitberger H, Gendy AE, Brunner M, Krautz C, Wolff K, Mihai S, Neufert C, Siebler J, Grützmann R, Weber GF, David P. Hansen FJ, et al. Among authors: neufert c. Sci Rep. 2024 Sep 10;14(1):21164. doi: 10.1038/s41598-024-70916-3. Sci Rep. 2024. PMID: 39256468 Free PMC article.
Good Manufacturing Practice-Compliant Production and Lot-Release of Ex Vivo Expanded Regulatory T Cells As Basis for Treatment of Patients with Autoimmune and Inflammatory Disorders.
Wiesinger M, Stoica D, Roessner S, Lorenz C, Fischer A, Atreya R, Neufert CF, Atreya I, Scheffold A, Schuler-Thurner B, Neurath MF, Schuler G, Voskens CJ. Wiesinger M, et al. Among authors: neufert cf. Front Immunol. 2017 Oct 26;8:1371. doi: 10.3389/fimmu.2017.01371. eCollection 2017. Front Immunol. 2017. PMID: 29123521 Free PMC article.
Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice.
Erkert L, Kabisch M, Gamez-Belmonte R, Gonzalez-Acera M, Patankar JV, Schödel L, Hofmann K, Wagner Y, Plattner C, Spath EM, Distler U, Tenzer S; TRR241 IBDome Consortium; Neufert C, Neurath MF, Becker C. Erkert L, et al. Among authors: neufert c. J Crohns Colitis. 2025 Jun 12:jjaf096. doi: 10.1093/ecco-jcc/jjaf096. Online ahead of print. J Crohns Colitis. 2025. PMID: 40503970
IL-36 signaling as a drug target in Crohn's disease patients with IL36RN mutations.
Hecker J, Plattner C, Cancino CA, Löscher BS, Saurenbach J, Letizia M, Rieder D; TRR241 IBDome Consortium; Freise I, Koop K, Neufert C, Kunkel D, Al Khatim Z, Schaafs LA, Schütz A, Becker C, Atreya R, Trajanoski Z, Franke A, Sonnenberg E, Hegazy AN, Siegmund B, Weidinger C. Hecker J, et al. Among authors: neufert c. EMBO Mol Med. 2025 May 30. doi: 10.1038/s44321-025-00245-z. Online ahead of print. EMBO Mol Med. 2025. PMID: 40447918 Free article.
The IL-22-oncostatin M axis promotes intestinal inflammation and tumorigenesis.
Cineus R, Luo Y, Saliutina M, Manna S, Cancino CA, Velasco Blázquez L, Wang L, Bösel D, Abdelrahman A, Klementowicz JE, Scherl A, Hainbuch S, Bréart B, Kwon G, Konopka A, Guerra GM, von Coburg E, Gerbeth L, Roels J, Heinrich F, Müller N, Durek P, Deigendesch N, Ziai J, Hung J, Conrad T; TRR241 IBDome Consortium; Kühl AA, Wirtz S, Löhning M, Keir M, Diefenbach A, Mashreghi MF, Siegmund B, Schumann M, Romagnani C, West NR, Hegazy AN. Cineus R, et al. Nat Immunol. 2025 Jun;26(6):837-853. doi: 10.1038/s41590-025-02149-z. Epub 2025 May 30. Nat Immunol. 2025. PMID: 40447860 Free PMC article.
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