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Comparative Efficacy of Virtual Reality-Assisted Cognitive Behavioral Therapy Versus Yoga-Based Interventions for Reducing Performance Anxiety in Students: Protocol for a Randomized Controlled Trial.
Tofan CM, Măgurianu LA, Axinte M, Găină AM, Găină M. Tofan CM, et al. JMIR Res Protoc. 2025 Jun 30;14:e66112. doi: 10.2196/66112. JMIR Res Protoc. 2025. PMID: 40587850
Statistical analyses will include parametric tests (eg, repeated-measures ANOVA and t tests) to compare anxiety reduction, emotional regulation, and quality of life across groups. ...
Statistical analyses will include parametric tests (eg, repeated-measures ANOVA and t tests) to compare anxiety reduction, emotional …
Improvements in Glycemic Control With a Digital Diabetes Logbook: Secondary Analysis of a Randomized Controlled Trial Enriched by Observational, Real-World Data.
Ehrmann D, Ruch B, Mitter M, Kober J, Hermanns N, Schäfer V, Kulzer B, Silbermann S. Ehrmann D, et al. J Med Internet Res. 2025 Jun 30;27:e68933. doi: 10.2196/68933. J Med Internet Res. 2025. PMID: 40587847
For the analysis of RWD, a total of 2861 participants with type 1 or type 2 diabetes were identified using propensity score matching to align their characteristics with those of the RCT participants closely. One-sample t tests were conducted to analyze changes in mean bloo …
For the analysis of RWD, a total of 2861 participants with type 1 or type 2 diabetes were identified using propensity score matching to alig …
Covalent Organic Frameworks-Delivered Reuterin Drives Trained Immunity in Tumor-Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism.
Zhang JG, Zhang XM, Wu X, Zhou CK, Liu ZZ, Luo XY, Zhang L, Chen W, Yang YJ. Zhang JG, et al. Adv Sci (Weinh). 2025 Jun 30:e04784. doi: 10.1002/advs.202504784. Online ahead of print. Adv Sci (Weinh). 2025. PMID: 40587842
Furthermore, COF-Reuterin reprogrammed TAMs from an M2 to an M1 phenotype, increasing CD8(+) T cell infiltration and decreasing myeloid-derived suppressor cells (MDSCs), reshaping the immunosuppressive tumor microenvironment. ...
Furthermore, COF-Reuterin reprogrammed TAMs from an M2 to an M1 phenotype, increasing CD8(+) T cell infiltration and decreasing myelo …
Ways to broaden the awareness, consideration and adoption of new approach methodologies (NAMs).
Oyetade O, Allen DG, Carder J, Farley-Dawson EA, Reinke E, Marko S, Kleinstreuer NC, Hogberg HT. Oyetade O, et al. ALTEX. 2025 Jun 26. doi: 10.14573/altex.2505281. Online ahead of print. ALTEX. 2025. PMID: 40587837
CAMWG asked questions concerning organizational views on NAMs, their use or consideration, and why they aren't used more often. Responses fit into five categories: perception, regulations, scientific/technical, education, and financial consideration. ...
CAMWG asked questions concerning organizational views on NAMs, their use or consideration, and why they aren't used more often. Respo …
PGI2 signaling metabolically reprograms CD4 Th2 cells and represses allergic airway inflammation.
Zhou W, Zhang J, Chowdhury NU, Norlander AE, Toki S, Abney M, Rusznak M, Gibson-Corley KN, Cook DP, Newcomb DC, Peebles RS Jr. Zhou W, et al. J Immunol. 2025 Jun 30:vkaf130. doi: 10.1093/jimmun/vkaf130. Online ahead of print. J Immunol. 2025. PMID: 40587812
Prostaglandin I2 (PGI2) is a lipid mediator known to inhibit T helper 2 (Th2) immune responses and allergic inflammation, but its role in regulating Th2 cell metabolism remains underexplored. ...
Prostaglandin I2 (PGI2) is a lipid mediator known to inhibit T helper 2 (Th2) immune responses and allergic inflammation, but its rol …
Clinical application value of different SCC-Ag reference intervals.
Xie Q, Zhu L, Zhang L, Fu S. Xie Q, et al. Medicine (Baltimore). 2025 Jun 27;104(26):e42964. doi: 10.1097/MD.0000000000042964. Medicine (Baltimore). 2025. PMID: 40587743
The study retrospectively analyzed data from 5251 healthy individuals to develop a locally applicable SCC-Ag reference interval, following guidelines from the CLSI-C28-A3c document and the WS/T 402-2012 Clinical Laboratory Test Project Reference Range. Subsequently, a coho …
The study retrospectively analyzed data from 5251 healthy individuals to develop a locally applicable SCC-Ag reference interval, following g …
Improving cutaneous melanoma prognosis through adjusting PSMB9 expression: A diagnostic accuracy study based on the construction and optimization of an artificial neural network model.
Li D, Guan Z, Liu Y, Li X. Li D, et al. Medicine (Baltimore). 2025 Jun 27;104(26):e42545. doi: 10.1097/MD.0000000000042545. Medicine (Baltimore). 2025. PMID: 40587698
Statistical analysis of PSMB9 expression at various stages indicated that its expression decreases with the progression of the T stage, with no differences in the M- and N-stages. Immune infiltration analysis suggested that PSMB9 is also involved in regulating multiple imm …
Statistical analysis of PSMB9 expression at various stages indicated that its expression decreases with the progression of the T stag …
Association between high-sensitivity troponin and mortality risk in individuals with early kidney disease: A population-based cohort study.
Jiang MY, Wu WS. Jiang MY, et al. Medicine (Baltimore). 2025 Jun 27;104(26):e43014. doi: 10.1097/MD.0000000000043014. Medicine (Baltimore). 2025. PMID: 40587684
This study evaluated the association between high-sensitivity troponin I (hs-TnI) and troponin T (hs-TnT) with all-cause and cardiovascular mortality in this population. This retrospective cohort study used data from the 1999 to 2004 National Health and Nutrition Examinati …
This study evaluated the association between high-sensitivity troponin I (hs-TnI) and troponin T (hs-TnT) with all-cause and cardiova …
Integration of single-cell and bulk RNA data to identify key cell types and biomarkers in viral myocarditis: An integrated bioinformatics analysis.
Xie F, Li J. Xie F, et al. Medicine (Baltimore). 2025 Jun 27;104(26):e43033. doi: 10.1097/MD.0000000000043033. Medicine (Baltimore). 2025. PMID: 40587683
Receiver operating characteristic curves assessed the predictive performance of key factors in a validation cohort. T cells were re-annotated for higher-resolution subtyping, and pseudotime analysis depicted the cell trajectories of T cell subtypes. ...Pseudotime an …
Receiver operating characteristic curves assessed the predictive performance of key factors in a validation cohort. T cells were re-a …
RPA3 and RFC3 as biomarkers for myocardial infarction diagnosis under computed tomography angiography.
Zhang S, Peng R, Xin R, Shen X, Zheng J. Zhang S, et al. Medicine (Baltimore). 2025 Jun 27;104(26):e43087. doi: 10.1097/MD.0000000000043087. Medicine (Baltimore). 2025. PMID: 40587682
Furthermore, we analyzed the correlation between infiltrating immune cells and obtained a co-expression pattern diagram of immune cell components, indicating that when NK_cells_activated expression was high, T_cells_CD4_naive expression was also high. A highly positive cor …
Furthermore, we analyzed the correlation between infiltrating immune cells and obtained a co-expression pattern diagram of immune cell compo …
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