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Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier.
Moyer TC, Hoffman BA, Chen W, Shah I, Ren XQ, Knox T, Liu J, Wang W, Li J, Khalid H, Kulkarni AS, Egbuchulam M, Clement J, Bloedel A, Child M, Kaur R, Rouse E, Graham K, Maura D, Thorpe Z, Sayed-Zahid A, Hiu-Yan Chung C, Kutchin A, Johnson A, Yao J, Thompson J, Pande N, Nonnenmacher ME. Moyer TC, et al. Among authors: sayed zahid a. Mol Ther. 2025 May 8:S1525-0016(25)00373-9. doi: 10.1016/j.ymthe.2025.04.046. Online ahead of print. Mol Ther. 2025. PMID: 40340250 Free article.