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Page 1
Molecular analysis highlights TREM2 as a discriminating biomarker for patients suffering from pancreatic ductal adenocarcinoma.
Papakonstantinou D, Wang H, Bani MA, Mulder K, Dunsmore G, Boilève A, Jules-Clément G, Panunzi L, de Sousa LR, de la Calle Fabregat C, Deloger M, Signolle N, Gessain G, Nikolaev SI, Ducreux M, Hollebecque A, Ginhoux F, Blériot C. Papakonstantinou D, et al. Among authors: de la calle fabregat c. Cancer Treat Res Commun. 2025;43:100939. doi: 10.1016/j.ctarc.2025.100939. Epub 2025 May 7. Cancer Treat Res Commun. 2025. PMID: 40354768 Free article.
DNA methylome biomarkers of rheumatoid arthritis-associated interstitial lung disease reflecting lung fibrosis pathways, an exploratory case-control study.
Kaczmarczyk B, de la Calle-Fabregat C, Conde A, Duarte AC, Mena-Vazquez N, Fernandez-Nebro A, Triguero-Martinez A, Castañeda S, Dos-Santos Sobrin R, Mera-Varela A, Lopez-Pedrera C, Escudero-Contreras A, Vela-Casasempere P, Molina M, Narvaez J, Retuerto-Guerrero M, Pablos JL, Sarmiento-Monroy JC, Sanmarti R, Gomez-Carrera L, Bonilla G, Remuzgo-Martinez S, Gonzalez-Gay MA, Leiro-Fernandez V, Perez-Gomez N, Vadillo-Font C, Abasolo L, Casafont-Sole I, Mateo-Soria L, Castillo-Gonzalez AC, Marras C, Perez-Pampin E, Ballestar E, Gonzalez A; MARILD network. Kaczmarczyk B, et al. Among authors: de la calle fabregat c. Sci Rep. 2025 Apr 29;15(1):15123. doi: 10.1038/s41598-025-99755-6. Sci Rep. 2025. PMID: 40301499 Free PMC article.
COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation.
Rodríguez-Ubreva J, Calafell-Segura J, Calvillo CL, Keller B, Ciudad L, Handfield LF, de la Calle-Fabregat C, Godoy-Tena G, Andrés-León E, Hoo R, Porter T, Prigmore E, Hofmann M, Decker A, Martín J, Vento-Tormo R, Warnatz K, Ballestar E. Rodríguez-Ubreva J, et al. Among authors: de la calle fabregat c. Nat Commun. 2024 Nov 28;15(1):10344. doi: 10.1038/s41467-024-54732-x. Nat Commun. 2024. PMID: 39609471 Free PMC article.
NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment.
de la Calle-Fabregat C, Calafell-Segura J, Gardet M, Dunsmore G, Mulder K, Ciudad L, Silvin A, Moreno-Càceres J, Corbí ÁL, Muñoz-Pinedo C, Michels J, Gouy S, Dutertre CA, Rodríguez-Ubreva J, Ginhoux F, Ballestar E. de la Calle-Fabregat C, et al. Sci Adv. 2024 Sep 20;10(38):eadq5226. doi: 10.1126/sciadv.adq5226. Epub 2024 Sep 18. Sci Adv. 2024. PMID: 39292770 Free PMC article.
Timing and location dictate monocyte fate and their transition to tumor-associated macrophages.
Dunsmore G, Guo W, Li Z, Bejarano DA, Pai R, Yang K, Kwok I, Tan L, Ng M, De La Calle Fabregat C, Yatim A, Bougouin A, Mulder K, Thomas J, Villar J, Bied M, Kloeckner B, Dutertre CA, Gessain G, Chakarov S, Liu Z, Scoazec JY, Lennon-Dumenil AM, Marichal T, Sautès-Fridman C, Fridman WH, Sharma A, Su B, Schlitzer A, Ng LG, Blériot C, Ginhoux F. Dunsmore G, et al. Among authors: de la calle fabregat c. Sci Immunol. 2024 Jul 26;9(97):eadk3981. doi: 10.1126/sciimmunol.adk3981. Epub 2024 Jul 26. Sci Immunol. 2024. PMID: 39058763
Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection.
Barmada A, Handfield LF, Godoy-Tena G, de la Calle-Fabregat C, Ciudad L, Arutyunyan A, Andrés-León E, Hoo R, Porter T, Oszlanczi A, Richardson L, Calero-Nieto FJ, Wilson NK, Marchese D, Sancho-Serra C, Carrillo J, Presas-Rodríguez S, Ramo-Tello C, Ruiz-Sanmartin A, Ferrer R, Ruiz-Rodriguez JC, Martínez-Gallo M, Munera-Campos M, Carrascosa JM, Göttgens B, Heyn H, Prigmore E, Casafont-Solé I, Solanich X, Sánchez-Cerrillo I, González-Álvaro I, Raimondo MG, Ramming A, Martin J, Martínez-Cáceres E, Ballestar E, Vento-Tormo R, Rodríguez-Ubreva J. Barmada A, et al. Among authors: de la calle fabregat c. Eur J Immunol. 2024 Jan;54(1):e2350633. doi: 10.1002/eji.202350633. Epub 2023 Oct 20. Eur J Immunol. 2024. PMID: 37799110 Free article.
Inherited human ezrin deficiency impairs adaptive immunity.
García-Solís B, Van Den Rym A, Martinez-Martínez L, Franco T, Pérez-Caraballo JJ, Markle J, Cubillos-Zapata C, Marín AV, Recio MJ, Regueiro JR, Navarro-Zapata A, Mestre-Durán C, Ferreras C, Martín Cotázar C, Mena R, de la Calle-Fabregat C, López-Lera A, Fernández Arquero M, Pérez-Martínez A, López-Collazo E, Sánchez-Ramón S, Casanova JL, Martínez-Barricarte R, de la Calle-Martín O, Pérez de Diego R. García-Solís B, et al. Among authors: de la calle fabregat c. J Allergy Clin Immunol. 2023 Oct;152(4):997-1009.e11. doi: 10.1016/j.jaci.2023.05.022. Epub 2023 Jun 8. J Allergy Clin Immunol. 2023. PMID: 37301410 Free PMC article.
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines.
Godoy-Tena G, Barmada A, Morante-Palacios O, de la Calle-Fabregat C, Martins-Ferreira R, Ferreté-Bonastre AG, Ciudad L, Ruiz-Sanmartín A, Martínez-Gallo M, Ferrer R, Ruiz-Rodriguez JC, Rodríguez-Ubreva J, Vento-Tormo R, Ballestar E. Godoy-Tena G, et al. Among authors: de la calle fabregat c. Genome Med. 2022 Nov 29;14(1):134. doi: 10.1186/s13073-022-01137-4. Genome Med. 2022. PMID: 36443794 Free PMC article.
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses.
Rodríguez-Ubreva J, Arutyunyan A, Bonder MJ, Del Pino-Molina L, Clark SJ, de la Calle-Fabregat C, Garcia-Alonso L, Handfield LF, Ciudad L, Andrés-León E, Krueger F, Català-Moll F, Rodríguez-Cortez VC, Polanski K, Mamanova L, van Dongen S, Kiselev VY, Martínez-Saavedra MT, Heyn H, Martín J, Warnatz K, López-Granados E, Rodríguez-Gallego C, Stegle O, Kelsey G, Vento-Tormo R, Ballestar E. Rodríguez-Ubreva J, et al. Among authors: de la calle fabregat c. Nat Commun. 2022 Apr 1;13(1):1779. doi: 10.1038/s41467-022-29450-x. Nat Commun. 2022. PMID: 35365635 Free PMC article.
15 results