BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.
Varkaris A, Wang K, Nouri M, Kozlova N, Schmidt DR, Stavridi A, Arai S, Ambrosio N, Poluben L, Jimenez-Vacas JM, Westaby D, Carmichael J, Xie F, Figueiredo I, Buroni L, Neeb A, Gurel B, Chevalier N, Brown L, Voznesensky O, Chen SY, Russo JW, Yuan X, Juric D, Beltran H, De Bono JS, Vander Heiden MG, Einstein DJ, Muranen T, Corey E, Sharp A, Balk SP.
Varkaris A, et al. Among authors: corey e.
Nat Commun. 2025 May 28;16(1):4931. doi: 10.1038/s41467-025-60238-x.
Nat Commun. 2025.
PMID: 40436896
Free PMC article.