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Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life.
Latina V, De Introna M, Malerba F, Florio R, Balzamino BO, Di Natale G, Sciacca MFM, Pappalardo G, Micera A, Pignataro A, Calissano P, Amadoro G. Latina V, et al. Among authors: amadoro g. Acta Neuropathol Commun. 2025 May 29;13(1):121. doi: 10.1186/s40478-025-02022-y. Acta Neuropathol Commun. 2025. PMID: 40442822 Free PMC article.
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease.
Latina V, Giacovazzo G, Cordella F, Balzamino BO, Micera A, Varano M, Marchetti C, Malerba F, Florio R, Ercole BB, La Regina F, Atlante A, Coccurello R, Di Angelantonio S, Calissano P, Amadoro G. Latina V, et al. Among authors: amadoro g. Acta Neuropathol Commun. 2021 Mar 9;9(1):38. doi: 10.1186/s40478-021-01138-1. Acta Neuropathol Commun. 2021. PMID: 33750467 Free PMC article.
Dynamic structural determinants underlie the neurotoxicity of the N-terminal tau 26-44 peptide in Alzheimer's disease and other human tauopathies.
Perini G, Ciasca G, Minelli E, Papi M, Palmieri V, Maulucci G, Nardini M, Latina V, Corsetti V, Florenzano F, Calissano P, De Spirito M, Amadoro G. Perini G, et al. Among authors: amadoro g. Int J Biol Macromol. 2019 Dec 1;141:278-289. doi: 10.1016/j.ijbiomac.2019.08.220. Epub 2019 Aug 27. Int J Biol Macromol. 2019. PMID: 31470053
Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models.
Corsetti V, Borreca A, Latina V, Giacovazzo G, Pignataro A, Krashia P, Natale F, Cocco S, Rinaudo M, Malerba F, Florio R, Ciarapica R, Coccurello R, D'Amelio M, Ammassari-Teule M, Grassi C, Calissano P, Amadoro G. Corsetti V, et al. Among authors: amadoro g. Brain Commun. 2020 Apr 6;2(1):fcaa039. doi: 10.1093/braincomms/fcaa039. eCollection 2020. Brain Commun. 2020. PMID: 32954296 Free PMC article.
64 results