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Page 1
Secretion of a VEGF-blocking scFv enhances CAR T-cell potency.
Supper VM, Donner H, Birocchi F, Bratt A, Escobar G, Kann MC, Park S, Martin G, Korell F, Takei H, Armstrong A, Parker A, Salas-Benito D, Darnell EP, Bailey SR, Kienka T, Philips M, Bouffard A, Goncalves S, Choi BD, Haradhvala NJ, Maus MV, Leick MB. Supper VM, et al. Cancer Immunol Res. 2025 Jun 2. doi: 10.1158/2326-6066.CIR-24-0876. Online ahead of print. Cancer Immunol Res. 2025. PMID: 40455064
IFN-γ-resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models.
Bailey SR, Takei HN, Escobar G, Kann MC, Bouffard AA, Kienka T, Supper VM, Armstrong A, Salas-Benito D, Phillips MK, Birocchi F, Vatsa S, Silva H, Scarfò I, Wehrli M, Grauwet K, Darnell EP, Graham CE, Leick MB, Korell F, Berger TR, Maus MV. Bailey SR, et al. Among authors: supper vm. Sci Transl Med. 2025 Jun 4;17(801):eadp8166. doi: 10.1126/scitranslmed.adp8166. Epub 2025 Jun 4. Sci Transl Med. 2025. PMID: 40465687