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Page 1
Pharmacokinetics Analysis of Serum and Rectal Tissue Concentrations of a Pair of Anti-HIV Monoclonal Antibodies, VRC01 and VRC01LS, in Adults without HIV.
Huang Y, Zhang L, Lemos MP, Astronomo RD, Narpala S, Prabhakaran M, Garcia NMG, Lu Y, Mize GJ, Glantz H, Colegrove H, Mann P, Paez CA, Andersen-Nissen E, Hutter J, Dumond J, McDermott AB, Mascola JR, Koup RA, Bekker LG, McElrath MJ. Huang Y, et al. Among authors: narpala s. J Clin Pharmacol. 2025 Jun 8. doi: 10.1002/jcph.70060. Online ahead of print. J Clin Pharmacol. 2025. PMID: 40485091
Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response.
Matsuda K, Harrison M, Wettstein E, Pederson J, Pullano AA, Bolkhovitinov L, Kim B, Steinberg I, Griesman T, Stuccio S, Rogan D, Patamawenu A, Shofner T, Wright NE, Webber JD, Van't Veer F, Roenicke R, Koory E, Roeder PM, Ober E, Leach B, Tsybovsky Y, Stephens T, Del Moral-Sanchez I, Bontjer I, McGinnes-Cullen LW, Chu E, Liang J, Torres JL, Lin RN, Tran AS, Dziubla G, Serebryannyy L, Narpala S, Lin B, Castro M, Ozorowski G, Ward AB, Sanders RW, Kwong PD, Guenaga J, Wyatt R, Morrison T, Connors M. Matsuda K, et al. Among authors: narpala s. Nat Commun. 2025 Jun 3;16(1):5162. doi: 10.1038/s41467-025-60481-2. Nat Commun. 2025. PMID: 40461490 Free PMC article.
Population pharmacokinetics of weight-based compared with fixed dosing of CAP256V2LS, a broadly neutralizing antibody for HIV prevention in women.
Mahomed S, Beliveau M, Heredia-Ortiz R, Osman F, Letsoalo M, Garrett N, Gengiah TN, Archary D, Wang J, Narpala S, Castro M, Serebryannyy L, Carlton K, Koup RA, Moore PL, Morris L, Abdool Karim Q, Abdool Karim SS. Mahomed S, et al. Among authors: narpala s. J Antimicrob Chemother. 2025 Jun 3:dkaf181. doi: 10.1093/jac/dkaf181. Online ahead of print. J Antimicrob Chemother. 2025. PMID: 40458046
Safety and pharmacokinetics of N6LS, a broadly neutralising monoclonal antibody for HIV: a phase 1, open-label, dose-escalation study in healthy adults.
Wu RL, Houser KV, Gaudinski MR, Widge AT, Awan SF, Carter CA, Holman LA, Saunders J, Hendel CS, Eshun A, Whalen WR, Wang X, Arthur A, Cunningham JE, Beck A, Casazza JP, Yamshchikov GV, Rothwell RS, Strom L, Dittakavi T, Happe M, Hickman SP, Conan-Cibotti M, Carlton K, Zhang L, Huang Y, Capparelli EV, Castro M, Lin BC, O'Connell S, Flach BS, Bailer RT, Narpala SR, Serebryannyy L, McDermott AB, Arnold FJ, Gall JG, Vazquez S, Berkowitz NM, Gordon IJ, Chen GL, Kwong PD, Huang J, Pierson TC, Connors M, Mascola JR, Zhou T, Doria-Rose NA, Koup RA, Dropulic LK; VRC 609 study team. Wu RL, et al. Among authors: narpala sr. Lancet HIV. 2025 Jul;12(7):e485-e495. doi: 10.1016/S2352-3018(25)00041-4. Epub 2025 May 20. Lancet HIV. 2025. PMID: 40409326 Clinical Trial.
Prospective SARS-CoV-2 Booster Vaccination in Immunosuppressant-Treated Systemic Autoimmune Disease Patients in a Randomized Controlled Trial.
Mackay M, Wagner CA, Pinckney A, Cohen JA, Wallace ZS, Khosroshahi A, Sparks JA, Lord S, Saxena A, Caricchio R, Kim AH, Kamen DL, Koumpouras F, Askanase AD, Smith K, Guthridge JM, Pardo G, Mao-Draayer Y, Macwana S, McCarthy S, Sherman MA, Hamrah SD, Veri M, Walker S, York K, Tedeschi S, Wang J, Dziubla G, Castro M, Carroll R, Narpala S, Lin BC, Serebryannyy L, McDermott A; ACV01 Study Team; Barry WT, Goldmuntz E, McNamara J, Payne AS, Bar-Or A, Khanna D, James JA. Mackay M, et al. Among authors: narpala s. medRxiv [Preprint]. 2025 Mar 26:2025.03.25.25324558. doi: 10.1101/2025.03.25.25324558. medRxiv. 2025. PMID: 40196267 Free PMC article. Preprint.
Combination immunotherapy induces post-intervention control of HIV.
Peluso MJ, Sandel DA, Deitchman AN, Kim SJ, Dalhuisen T, Tummala HP, Tibúrcio R, Zemelko L, Borgo GM, Singh SS, Schwartz K, Deswal M, Williams MC, Hoh R, Shimoda M, Narpala S, Serebryannyy L, Khalili M, Vendrame E, SenGupta D, Whitmore LS, Tisoncik-Go J, Gale M Jr, Koup RA, Mullins JI, Felber BK, Pavlakis GN, Reeves JD, Petropoulos CJ, Glidden DV, Spitzer MH, Gama L, Caskey M, Nussenzweig MC, Chew KW, Henrich TJ, Yukl SA, Cohn LB, Deeks SG, Rutishauser RL. Peluso MJ, et al. Among authors: narpala s. Res Sq [Preprint]. 2025 Mar 19:rs.3.rs-6141479. doi: 10.21203/rs.3.rs-6141479/v1. Res Sq. 2025. PMID: 40166020 Free PMC article. Preprint.
Virologic effects of broadly neutralizing antibodies VRC01LS and VRC07-523LS on chronic HIV-1 infection.
Happe M, Lynch RM, Fichtenbaum CJ, Heath SL, Koletar SL, Landovitz RJ, Presti RM, Santana-Bagur JL, Tressler RL, Holman LA, Novik L, Roa JC, Rothwell RS, Strom L, Wang J, Hu Z, Conan-Cibotti M, Bhatnagar AM, Dwyer B, Ko SH, Belinky F, Namboodiri AM, Pandey JP, Carroll R, Basappa M, Serebryannyy L, Narpala SR, Lin BC, McDermott AB, Boritz EA, Capparelli EV, Coates EE, Koup RA, Ledgerwood JE, Mascola JR, Chen GL, Tebas P; VRC 607/A5378 Study Team. Happe M, et al. Among authors: narpala sr. JCI Insight. 2025 Feb 24;10(4):e181496. doi: 10.1172/jci.insight.181496. JCI Insight. 2025. PMID: 39989458 Free PMC article. Clinical Trial.
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350.
Joyce MG, Bu W, Chen WH, Gillespie RA, Andrews SF, Wheatley AK, Tsybovsky Y, Jensen JL, Stephens T, Prabhakaran M, Fisher BE, Narpala SR, Bagchi M, McDermott AB, Nabel GJ, Kwong PD, Mascola JR, Cohen JI, Kanekiyo M. Joyce MG, et al. Among authors: narpala sr. Immunity. 2025 Feb 11;58(2):295-308.e5. doi: 10.1016/j.immuni.2025.01.010. Epub 2025 Feb 4. Immunity. 2025. PMID: 39909035 Free article.
Enhanced and sustained biodistribution of HIV-1 neutralizing antibody VRC01LS in human genital and rectal mucosa.
Lemos MP, Astronomo RD, Huang Y, Narpala S, Prabhakaran M, Mann P, Paez CA, Lu Y, Mize GJ, Glantz H, Westerberg K, Colegrove H, Smythe KS, Lin M, Pierce RH, Hutter J, Frank I, Mascola JR, McDermott AB, Bekker LG, McElrath MJ. Lemos MP, et al. Among authors: narpala s. Nat Commun. 2024 Nov 28;15(1):10332. doi: 10.1038/s41467-024-54580-9. Nat Commun. 2024. PMID: 39609400 Free PMC article. Clinical Trial.
Neutralizing antibody correlate of protection against severe-critical COVID-19 in the ENSEMBLE single-dose Ad26.COV2.S vaccine efficacy trial.
Carpp LN, Hyrien O, Fong Y, Benkeser D, Roels S, Stieh DJ, Van Dromme I, Van Roey GA, Kenny A, Huang Y, Carone M, McDermott AB, Houchens CR, Martins K, Jayashankar L, Castellino F, Amoa-Awua O, Basappa M, Flach B, Lin BC, Moore C, Naisan M, Naqvi M, Narpala S, O'Connell S, Mueller A, Serebryannyy L, Castro M, Wang J, Petropoulos CJ, Luedtke A, Lu Y, Yu C, Juraska M, Hejazi NS, Wolfe DN, Sadoff J, Gray GE, Grinsztejn B, Goepfert PA, Bekker LG, Gaur AH, Veloso VG, Randhawa AK, Andrasik MP, Hendriks J, Truyers C, Vandebosch A, Struyf F, Schuitemaker H, Douoguih M, Kublin JG, Corey L, Neuzil KM, Follmann D, Koup RA, Donis RO, Gilbert PB; Immune Assays Team; Coronavirus Vaccine Prevention Network (CoVPN)/ENSEMBLE Team; United States Government (USG)/CoVPN Biostatistics Team. Carpp LN, et al. Among authors: narpala s. Nat Commun. 2024 Nov 12;15(1):9785. doi: 10.1038/s41467-024-53727-y. Nat Commun. 2024. PMID: 39532861 Free PMC article. Clinical Trial.
84 results