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A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss.
Cal K, Leyva A, Rodríguez-Duarte J, Ruiz S, Santos L, Garat MP, Colella L, Ingold M, Benitez-Rosendo A, Pérez-Torrado V, Vilaseca C, Galliussi G, Ziegler L, Peclat TR, Bresque M, Handy RM, King R, Menezes Dos Reis L, Alves JM, Espasandín C, de la Sovera V, Breining P, Dapueto R, Lopez A, Thompson KL, Lino CA, França JV, Vieira TS, Rattan R, Agorrody G, DeVallance E, Haag J, Meadows E, Lewis SE, Santana Barbosa GC, Lai de Souza LO, Chichierchio MS, Valez V, Aicardo A, Contreras P, Vendelbo MH, Jakobsen S, Kamaid A, Porcal W, Calliari A, Verdes JM, Du J, Wang Y, Hollander JM, White TA, Radi R, Moyna G, Quijano C, O'Doherty R, Moraes-Vieira P, Giri S, Holloway GP, Festuccia WT, Leiria LO, Leonardi R, Mori MA, Camacho-Pereira J, Kelley EE, Duran R, López GV, Chini EN, Batthyány C, Escande C. Cal K, et al. Among authors: batthyany c. Nat Metab. 2025 Jun 17. doi: 10.1038/s42255-025-01311-z. Online ahead of print. Nat Metab. 2025. PMID: 40527924
A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis.
Cal K, Leyva A, Rodríguez-Duarte J, Ruiz S, Santos L, Colella L, Ingold M, Vilaseca C, Galliussi G, Ziegler L, Peclat TR, Bresque M, Handy RM, King R, Dos Reis LM, Espasandin C, Breining P, Dapueto R, Lopez A, Thompson KL, Agorrody G, DeVallance E, Meadows E, Lewis SE, Barbosa GCS, de Souza LOL, Chichierchio MS, Valez V, Aicardo A, Contreras P, Vendelbo MH, Jakobsen S, Kamaid A, Porcal W, Calliari A, Verdes JM, Du J, Wang Y, Hollander JM, White TA, Radi R, Moyna G, Quijano C, O'Doherty R, Moraes-Vieira P, Holloway GP, Leonardi R, Mori MA, Camacho-Pereira J, Kelley EE, Duran R, Lopez GV, Batthyány C, Chini EN, Escande C. Cal K, et al. Among authors: batthyany c. Res Sq [Preprint]. 2023 Jul 12:rs.3.rs-3101395. doi: 10.21203/rs.3.rs-3101395/v1. Res Sq. 2023. Update in: Nat Metab. 2025 Jun 17. doi: 10.1038/s42255-025-01311-z. PMID: 37502859 Free PMC article. Updated. Preprint.
Electrophilic nitroalkene-tocopherol derivatives: synthesis, physicochemical characterization and evaluation of anti-inflammatory signaling responses.
Rodriguez-Duarte J, Dapueto R, Galliussi G, Turell L, Kamaid A, Khoo NKH, Schopfer FJ, Freeman BA, Escande C, Batthyány C, Ferrer-Sueta G, López GV. Rodriguez-Duarte J, et al. Among authors: batthyany c. Sci Rep. 2018 Aug 24;8(1):12784. doi: 10.1038/s41598-018-31218-7. Sci Rep. 2018. PMID: 30143727 Free PMC article.
A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition.
Ibarburu S, Kovacs M, Varela V, Rodríguez-Duarte J, Ingold M, Invernizzi P, Porcal W, Arévalo AP, Perelmuter K, Bollati-Fogolín M, Escande C, López GV, King P, Si Y, Kwon Y, Batthyány C, Barbeito L, Trias E. Ibarburu S, et al. Among authors: batthyany c. Neurotherapeutics. 2021 Jan;18(1):309-325. doi: 10.1007/s13311-020-00953-z. Epub 2020 Oct 28. Neurotherapeutics. 2021. PMID: 33118131 Free PMC article.
68 results