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3-Methylpyrazole-Mediated C-Terminal Protein Modification.
Zhang X, He C. Zhang X, et al. Org Lett. 2025 Jun 29. doi: 10.1021/acs.orglett.5c02315. Online ahead of print. Org Lett. 2025. PMID: 40581998
We present a mild, highly efficient, and selective method for the aminolysis of acyl pyrazole at protein C termini. The protocol demonstrates a broad substrate scope, operational simplicity, and aqueous-compatible conditions. Its successful application to site-specific …
We present a mild, highly efficient, and selective method for the aminolysis of acyl pyrazole at protein C termini. The protocol demo …
DeepExDC interprets genomic compartmentalization changes in single-cell Hi-C data.
Lyu H, Cao P, Long W, Yin X, Xu S, Fu L. Lyu H, et al. Brief Bioinform. 2025 May 1;26(3):bbaf301. doi: 10.1093/bib/bbaf301. Brief Bioinform. 2025. PMID: 40581982
Single-cell Hi-C (scHi-C) technology enables probing of higher-order chromatin structures in individual cells. ...Herein, we propose DeepExDC, an interpretable 1D convolutional neural network for differential analysis of A/B compartments in scHi-C data on a g …
Single-cell Hi-C (scHi-C) technology enables probing of higher-order chromatin structures in individual cells. ...Herein, we p …
Radical Sorting Catalysis via Bimolecular Homolytic Substitution (S(H)2): Opportunities for C(sp(3))-C(sp(3)) Cross-Coupling Reactions.
McWhinnie IM, Martin RT, Xie J, Chen R, Prieto Kullmer CN, MacMillan DWC. McWhinnie IM, et al. J Am Chem Soc. 2025 Jun 29. doi: 10.1021/jacs.5c07367. Online ahead of print. J Am Chem Soc. 2025. PMID: 40581978 Review.
The development of efficient C(sp(3))-C(sp(3)) cross-coupling methods that expand access to a pharmaceutically relevant three-dimensional chemical space represents a key frontier in organic synthesis. Traditional cross-coupling strategies readily achieve C(sp …
The development of efficient C(sp(3))-C(sp(3)) cross-coupling methods that expand access to a pharmaceutically relevant three- …
Impact of normobaric hyperoxia on finger vasomotor and thermoperceptual responses to local cold in normothermic and mildly hypothermic individuals.
Keramidas ME, Bowes HM, Moes MI, Eiken O, Gennser M. Keramidas ME, et al. Eur J Appl Physiol. 2025 Jun 29. doi: 10.1007/s00421-025-05869-0. Online ahead of print. Eur J Appl Physiol. 2025. PMID: 40581911
METHODS: Eight healthy men performed a 30-min normoxic and hyperoxic (100% O(2)) hand cold (8 C water) provocation, while immersed to the chest either in 35.1 (0.4)C (normothermic trial) or in 21.0 (0.1)C (hypothermic trial) water. ...
METHODS: Eight healthy men performed a 30-min normoxic and hyperoxic (100% O(2)) hand cold (8 C water) provocation, while immersed to …
Metal(loid)s and minerals in fish tissues: health risk-benefit assessment and variations by gender and size.
Varol M, Kaçar E, Polat Y. Varol M, et al. Environ Geochem Health. 2025 Jun 29;47(8):290. doi: 10.1007/s10653-025-02608-4. Environ Geochem Health. 2025. PMID: 40581900
Weekly consumption amounts below 210 g for C. carpio and below 280 g for T. tinca were deemed safe. The findings suggest that the nutritional benefits of these fish outweigh the potential health risks from metal(loid)s....
Weekly consumption amounts below 210 g for C. carpio and below 280 g for T. tinca were deemed safe. The findings suggest that the nut …
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