Pinheiro PSM - Search Results

1

Design, synthesis and pharmacological evaluation of multitarget GPR40 agonists/HDAC6 inhibitors for Alzheimer's disease.

Pinheiro PSM, de Chirico F, Loi M, Trazzi S, Ciani E, Rodrigues DA, Alves MA, Lima LM, Milelli A, Monti B, Manssour Fraga CA, Bolognesi ML. Pinheiro PSM, et al. Eur J Med Chem. 2025 Jun 13;296:117868. doi: 10.1016/j.ejmech.2025.117868. Online ahead of print. Eur J Med Chem. 2025. PMID: 40541115

2

Exploring the Conformational Effects of N- and C-Methylation of N-Acylhydrazones.

Franco LS, Alves MA, Sant'Anna CMR, de Sena Bastos IT, Barroso RCR, Costa FN, Ferreira FF, Fraga CAM, Barreiro EJ, Lima LM, Rodrigues DA, Pinheiro PSM. Franco LS, et al. Among authors: pinheiro psm. ACS Omega. 2025 Apr 21;10(17):17993-18004. doi: 10.1021/acsomega.5c01289. eCollection 2025 May 6. ACS Omega. 2025. PMID: 40352515 Free PMC article.

3

Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative.

Bastos ITS, Pinheiro PSM, Costa FN, Rocha MD, Sant'Anna CMR, Braz D, Souza ET, Martins MA, Barreiro EJ, Ferreira FF, Barroso RC, Fraga CAM. Bastos ITS, et al. Among authors: pinheiro psm. Pharmaceuticals (Basel). 2018 Nov 1;11(4):119. doi: 10.3390/ph11040119. Pharmaceuticals (Basel). 2018. PMID: 30388818 Free PMC article.

4

Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding Groups.

Pires GS, Tolomeu HV, Rodrigues DA, Lima LM, Fraga CAM, Pinheiro PSM. Pires GS, et al. Among authors: pinheiro psm. Pharmaceuticals (Basel). 2025 Apr 16;18(4):577. doi: 10.3390/ph18040577. Pharmaceuticals (Basel). 2025. PMID: 40284012 Free PMC article. Review.

5

Regioselective Nucleophilic Aromatic Substitution: Theoretical and Experimental Insights into 4-Aminoquinazoline Synthesis as a Privileged Structure in Medicinal Chemistry.

Barbosa MLC, Pinheiro PSM, Alves da Conceição R, Pires JR, Franco LS, Sant'Anna CMR, Barreiro EJ, Lima LM. Barbosa MLC, et al. Among authors: pinheiro psm. Molecules. 2024 Dec 20;29(24):6021. doi: 10.3390/molecules29246021. Molecules. 2024. PMID: 39770108 Free PMC article.

6

Remapping the Chemical Space and the Pharmacological Space of Drugs: What Can We Expect from the Road Ahead?

Franco LS, de Jesus BDSM, Pinheiro PSM, Fraga CAM. Franco LS, et al. Among authors: pinheiro psm. Pharmaceuticals (Basel). 2024 Jun 6;17(6):742. doi: 10.3390/ph17060742. Pharmaceuticals (Basel). 2024. PMID: 38931408 Free PMC article.

7

The Magic Methyl and Its Tricks in Drug Discovery and Development.

Pinheiro PSM, Franco LS, Fraga CAM. Pinheiro PSM, et al. Pharmaceuticals (Basel). 2023 Aug 15;16(8):1157. doi: 10.3390/ph16081157. Pharmaceuticals (Basel). 2023. PMID: 37631072 Free PMC article. Review.

8

Methyl Effect on the Metabolism, Chemical Stability, and Permeability Profile of Bioactive N-Sulfonylhydrazones.

Guedes JS, Carneiro TR, Pinheiro PSM, Fraga CAM, Sant Anna CMR, Barreiro EJ, Lima LM. Guedes JS, et al. Among authors: pinheiro psm. ACS Omega. 2022 Oct 19;7(43):38752-38765. doi: 10.1021/acsomega.2c04368. eCollection 2022 Nov 1. ACS Omega. 2022. PMID: 36340078 Free PMC article.

9

Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol-3-kinase (PI3K): Current and Future Prospects.

Rodrigues DA, Pinheiro PSM, Fraga CAM. Rodrigues DA, et al. Among authors: pinheiro psm. ChemMedChem. 2021 Feb 4;16(3):448-457. doi: 10.1002/cmdc.202000643. Epub 2020 Nov 6. ChemMedChem. 2021. PMID: 33049098 Review.

10

Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities.

Rodrigues DA, Pinheiro PSM, Sagrillo FS, Bolognesi ML, Fraga CAM. Rodrigues DA, et al. Among authors: pinheiro psm. Med Res Rev. 2020 Nov;40(6):2177-2211. doi: 10.1002/med.21701. Epub 2020 Jun 26. Med Res Rev. 2020. PMID: 32588916 Review.

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